PREDICTORS OF BEHAVIORAL DISTURBANCE IN ALZHEIMERS-DISEASE
PREDICTORS OF BEHAVIORAL DISTURBANCE IN ALZHEIMERS-DISEASE
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DOI：
10.1093/geronj/46.6.p362
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发表时间：
1991-11-01
期刊：
影响因子：
--
通讯作者：
FOX, JH
中科院分区：
文献类型：
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作者：
GILLEY, DW;WILSON, RS;FOX, JH
三项研究调查了阿尔茨海默病行为障碍与疾病严重程度、发病年龄和锥体外系体征的关系。通过与患者的主要照顾者进行结构化访谈，确定了五类行为障碍：冷漠、激动、精神病症状、去抑制和易怒。在研究1中，疾病严重程度的措施占冷漠量表方差的42%，但在其余量表的方差不到20%。在研究2中，锥体外系体征的存在与冷漠增加相关，并调节疾病严重程度与精神病症状和易怒量表之间的相关性。在研究3中，发病年龄与激越量表相关，并调节疾病严重程度与冷漠、精神病性症状和易怒量表之间的相关性。研究结果进行了讨论，在阿尔茨海默氏病的临床异质性，这些行为障碍的可能的生物学基础，以及与其测量相关的心理测量学问题。
The relationship of behavioral disturbances in Alzheimer's disease to disease severity, age at onset, and the presence of extrapyramidal signs was investigated in three studies. Five categories of behavior disturbance were ascertained through structured interview with the patient's primary caregiver: apathy, agitation, psychotic symptoms, disinhibition, and irritability. In Study 1, measures of disease severity accounted for 42% of the variance in the Apathy scale but less than 20% of the variance in the remaining scales. In Study 2, the presence of extrapyramidal signs was associated with increased Apathy and moderated the association between disease severity and the Psychotic Symptoms and Irritability scales. In Study 3, age at onset was associated with the Agitation scale and moderated the association between disease severity and the Apathy, Psychotic Symptoms, and Irritability scales. The findings are discussed in terms of the clinical heterogeneity within Alzheimer's disease, the possible biological bases of these behavioral disturbances, and the psychometric issues pertinent to their measurement.