Acute traumatic coagulopathy and trauma-induced coagulopathy: an overview.
Acute traumatic coagulopathy and trauma-induced coagulopathy: an overview.
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DOI：
10.1186/s40560-016-0196-6
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发表时间：
2017-01-20
影响因子：
7.1
通讯作者：
Kawazoe Y
中科院分区：
文献类型：
--
作者：
Kushimoto S;Kudo D;Kawazoe Y
出血是创伤患者急性期死亡的最重要因素。此前，创伤学家和研究人员确定了创伤后凝血病性出血的医源性和复苏相关原因，包括体温过低、代谢性酸中毒和稀释性凝血病，这些被认为是创伤后出血的主要驱动因素。然而，在过去的十年里，危重患者的复苏发生了广泛的范式转变，我们对创伤引起的凝血病的理解也发生了巨大的演变。尽管对于创伤相关性凝血障碍的定义或分类和命名方法尚未达成共识，但创伤本身和/或创伤性休克诱发的内源性凝血病均被称为急性创伤性凝血病（ATC），而多因素创伤相关性凝血障碍，包括ATC和复苏相关性凝血病被认为是创伤性凝血病。了解创伤引起的凝血病的病理生理学至关重要，特别是对于建立严重创伤患者治疗策略的关键问题而言。
Hemorrhage is the most important contributing factor of acute-phase mortality in trauma patients. Previously, traumatologists and investigators identified iatrogenic and resuscitation-associated causes of coagulopathic bleeding after traumatic injury, including hypothermia, metabolic acidosis, and dilutional coagulopathy that were recognized as primary drivers of bleeding after trauma. However, the last 10 years has seen a widespread paradigm shift in the resuscitation of critically injured patients, and there has been a dramatic evolution in our understanding of trauma-induced coagulopathy. Although there is no consensus regarding a definition or an approach to the classification and naming of trauma-associated coagulation impairment, trauma itself and/or traumatic shock-induced endogenous coagulopathy are both referred to as acute traumatic coagulopathy (ATC), and multifactorial trauma-associated coagulation impairment, including ATC and resuscitation-associated coagulopathy is recognized as trauma-induced coagulopathy. Understanding the pathophysiology of trauma-induced coagulopathy is vitally important, especially with respect to the critical issue of establishing therapeutic strategies for the management of patients with severe trauma.
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DOI：
10.1097/ta.0b013e3181da0da5
发表时间：
2010-06-01
影响因子：
--
作者：
Diaz, Jose J., Jr.;Cullinane, Daniel C.;Winston, Eleanor S.
通讯作者：
Winston, Eleanor S.
影响因子：
8.8
作者：
GANDO, S;NAKANISHI, Y;TEDO, I
通讯作者：
TEDO, I
影响因子：
9
作者：
Cotton BA;Reddy N;Hatch QM;LeFebvre E;Wade CE;Kozar RA;Gill BS;Albarado R;McNutt MK;Holcomb JB
通讯作者：
Holcomb JB
影响因子：
3.7
作者：
Campbell JE;Meledeo MA;Cap AP
通讯作者：
Cap AP
影响因子：
4.4
作者：
Esmon, CT
通讯作者：
Esmon, CT