Estimating the Heritability of Hair Curliness in Twins of European Ancestry
Estimating the Heritability of Hair Curliness in Twins of European Ancestry
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DOI：
10.1375/twin.12.5.514
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发表时间：
2009-10
影响因子：
0.9
通讯作者：
S. Medland;G. Zhu;N. Martin
中科院分区：
文献类型：
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作者：
S. Medland;G. Zhu;N. Martin
最近对亚洲人群的研究发现了EDAR和FGFR2基因的变异，这些变异出现在亚洲人和欧洲人的分化之后，并且与浓密的直发有关。到目前为止，还没有发现影响欧洲人头发质地的基因变异。在当前的研究中，我们在三个未选择的以欧洲血统为主的样本（NS1 = 2717; NS2 = 3904; NS3 = 5079）中检测了头发卷曲的遗传性。当使用三分制（直发/卷发/卷发）对男性进行评分时，男性比女性多出5%的可能性，数据显示，卷发随着年龄的增长略有增加。在样本中检测到显著的加性和显性遗传影响，导致广义遗传率为85-95%。鉴于EDAR对亚洲人群头发形态影响的大小和特异性，我们希望未来的关联研究能够在欧洲人群中发现类似的遗传影响。
Abstract Recent studies in Asian populations have identified variants in the EDAR and FGFR2 genes that arose following the divergence of Asians and Europeans and are associated with thick straight hair. To date no genetic variants have been identified influencing hair texture in Europeans. In the current study we examined the heritability of hair curliness in three unselected samples of predominantly European ancestry (NS1 = 2717; NS2 = 3904; NS3 = 5079). When rated using a three point scale (Straight/Wavy/Curly) males were ~5% more likely to report straight hair than females and there were suggestions in the data that curliness increased slightly with age. Across samples significant additive and dominant genetic influences were detected resulting in a broad sense heritability of 85–95%. Given the magnitude and the specificity of the EDAR effect on hair morphology in Asian populations we are hopeful that future association studies will detect similar genetic influences in European populations.