EFFECT OF STIMULATION OF THE VAGUS NERVE IN BURSTS ON GASTRIC-ACID SECRETION AND MOTILITY IN THE ANESTHETIZED FERRET
EFFECT OF STIMULATION OF THE VAGUS NERVE IN BURSTS ON GASTRIC-ACID SECRETION AND MOTILITY IN THE ANESTHETIZED FERRET
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DOI：
10.1113/jphysiol.1982.sp014463
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发表时间：
1982-01-01
影响因子：
5.5
通讯作者：
SCRATCHERD, T
中科院分区：
文献类型：
--
作者：
GRUNDY, D;SCRATCHERD, T
在麻醉的雪貂上，研究了以不同形式的脉冲（刺激总数保持恒定）电刺激迷走神经对胃酸分泌和胃运动的影响。使用三种刺激模式：连续的，突发在10倍的连续频率，但为10日的时间，和一个自然的突发模式从迷走神经传出纤维放电的记录。自然爆发模式引起胃收缩的幅度大于人工爆发或连续刺激，而连续刺激引起更大的变化，紧张。然而，酸分泌减少的自然模式的刺激相比，在连续刺激的输出，但在较小程度上比由于人工爆发刺激。以10脉冲/s的脉冲串刺激导致比等效连续刺激更大的酸输出和更大的胃收缩幅度。这种增强作用在刺激频率apprx下丧失。30脉冲/秒。在60和120脉冲/s的爆发频率下，分别与6和12脉冲/s的连续刺激相比，酸输出和收缩幅度显著降低。这些结果进行了讨论，在麻醉雪貂迷走神经放电的不同模式的功能意义。
The effect of electrical stimulation of the vagus nerve with different patterns of impulses (the total number of stimuli remaining constant) on gastric acid secretion and gastric motility were investigated in the anesthetized ferret. Three stimulus patterns were used: continuous, bursts at 10 times the continuous frequency but for a 10th of the time, and a natural burst pattern obtained from a recording of vagal efferent fiber discharge. The natural burst pattern gave rise to gastric contractions of larger amplitude than either the artificial burst or continuous stimulation, while continuous stimulation gave rise to larger changes in tonus. Acid secretion, however, was reduced by the natural pattern of stimulation as compared to the output during continuous stimulation, but to a lesser extent than that due to artificial burst stimulation. Burst stimulation at 10 impulses/s resulted in a larger output of acid and greater amplitude of gastric contraction than the equivalent continuous stimulation. This potentiation was lost at stimulation frequencies .apprx. 30 impulses/s. At burst frequencies of 60 and 120 impulses/s, there was a marked reduction in acid output and amplitude of contraction as compared with continuous stimulation at 6 and 12 impulses/s, respectively. These results are discussed in relation to the functional significance of the different patterns of vagal discharge seen in the anesthetized ferret.