The association of brachial artery diameter with noncalcified coronary plaque burden in apparently healthy individuals.
The association of brachial artery diameter with noncalcified coronary plaque burden in apparently healthy individuals.
复制标题
表面健康个体中肱动脉直径与非钙化冠状动脉斑块负荷的关系。
DOI：
10.1097/mca.0000000000000034
复制
发表时间：
2013
影响因子：
1.8
通讯作者：
Becker,LewisC
中科院分区：
文献类型：
--
作者：
Vaidya,Dhananjay;Kral,BrianG;Yanek,LisaR;Moy,TarynF;Fishman,ElliotK;Becker,DianeM;Becker,LewisC
冠状动脉粥样硬化与系统性动脉重构相关，即使在非动脉粥样硬化血管中也是如此。然而，目前尚不清楚系统性重塑是否与累积性动脉粥样硬化过程（反映为脓性静止钙化斑块（CP））或与活动性动脉粥样硬化（包括非钙化斑块（NCP））有差异相关。因此，我们研究了肱动脉直径（BAD）与冠状动脉CP和NCP的存在和程度之间的关系，BAD是一种不会发生临床动脉粥样硬化的动脉，来自350个有早发性冠状动脉疾病病史的家庭的无症状参与者通过使用双源计算机断层扫描血管造影术测量冠状动脉疾病危险因素和冠状动脉斑块，使用经验证的自动化方法定量空斑体积。BAD在术中使用B型超声测量。静息BAD与任何可检测到的斑块，对数转换CP和NCP的体积，如果检测到的关联，进行了测试，使用广义估计方程调整年龄，性别，种族，目前吸烟，糖尿病，高血压，BMI，非HDL和HDL cholesterol.ResultsHigher五分位数的BAD与更大的年龄和男性性别（均P< 0.001）。在完全调整后的分析中，CP体积与BAD无关（P= 0.65），但NCP体积增加1 ml与BAD增加0.65 mm相关（P= 0.027），但不影响正常人的生活质量。结论非动脉粥样硬化动脉的系统性动脉重构是一个动态的过程，与远处动脉粥样硬化活动程度相关，而与非活动性动脉粥样硬化累积程度无关。牙菌斑负担
ObjectiveCoronary atherosclerosis has been associated with systemic arterial remodeling even in nonatherosclerotic vessels. However, it is not known whether systemic remodeling is differentially associated with the cumulative atherosclerotic process, reflected by putatively quiescent calcified plaque (CP), or with active atherosclerosis, consisting of noncalcified plaque (NCP). We thus examined the association of brachial artery diameter (BAD), an artery that does not suffer clinical atherosclerosis, with the presence and the extent of coronary CP and NCP.MethodsWe studied 688 apparently healthy, asymptomatic participants from 350 families with a history of early-onset coronary artery disease (< 60 years of age) by measuring coronary artery disease risk factors and coronary plaque using dual-source computed tomographic angiography. Plaque volumes were quantified using a validated automated method. BAD was measured during diastole using B-mode ultrasound. The association of resting BAD with any detectable plaque, and log-transformed CP and NCP volumes if detectable, was tested using generalized estimating equations adjusted for age, sex, race, current smoking, diabetes, hypertension, BMI, and non-HDL and HDL cholesterol.ResultsHigher quintiles of BAD were associated with greater age and male sex (both P< 0.001). In the fully adjusted analysis, CP volume was not associated with BAD (P= 0.65) but a 1 ml greater NCP volume was associated with a 0.65 mm larger BAD (P= 0.027).ConclusionOur results suggest that systemic arterial remodeling of nonatherosclerotic arteries is a dynamic process that is correlated with the extent of putatively active atherosclerotic processes in distant beds but not with inactive accumulated plaque burden.