Chromosome 17-linked dementias.
Chromosome 17-linked dementias.
复制标题
17 号染色体连锁痴呆。
DOI：
10.1007/s000180050221
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发表时间：
1998
期刊：
影响因子：
--
通讯作者：
Wilhelmsen,KC
中科院分区：
文献类型：
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作者：
Wilhelmsen,KC
17号染色体连锁的痴呆症已经通过连锁分析被定义。据估计，这些综合征中最常见的是所有痴呆症的2%至20%的原因，并且交替地被称为额颞叶痴呆症、皮克病（没有皮克体）和缺乏独特特征的痴呆症[1 - 3]。在一组临床和病理异质性疾病中鉴定出导致这些疾病的突变可能使我们对神经变性的过程有更广泛的了解。
Chromosome 17-linked dementias have been defined by linkage analysis. The most common of these syndromes has been estimated to be the cause of between 2 and 20% of all dementia and has alternately been called frontotemporal dementia, Pick's disease (without Pick bodies) and dementia lacking distinctive features [1 – 3]. The identification of the mutation responsible for these conditions in a group of clinically and pathologically heterogeneous disorders may allow us to gain broad insight into the processes of neurodegeneration.