The Association Between Fetal and Postnatal Growth Status and Serum Levels of Uric Acid in Children at 3 Years of Age
The Association Between Fetal and Postnatal Growth Status and Serum Levels of Uric Acid in Children at 3 Years of Age
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DOI：
10.1038/ajh.2009.12
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发表时间：
2009-04-01
影响因子：
3.2
通讯作者：
Park, Hyesook
中科院分区：
文献类型：
--
作者：
Park, Bohyun;Park, Eunae;Park, Hyesook
背景最近的研究表明，尿酸在与出生体重相关的高血压的发展中起着因果作用。这项研究的目的是阐明产前和/或产后的生长状况对血清尿酸水平的儿童在3岁的age.METHODSA共178名儿童出生队列梨花女子大学医院进行了跟踪。在3岁时测量人体测量学特征、血压和血清尿酸。结果高血压儿童的血清尿酸水平（3.8 mg/dl）显著高于非高血压儿童（3.4 mg/dl）。早产和胎盘重量较低是与儿童早期血尿酸升高显著相关的早产因素。此外，当前体重、体重指数和体重变化s.d.从出生到现在的评分也与血清尿酸水平有关。体重和体重增加的第一和第四分位数组的血清尿酸水平较高。我们发现，最高的尿酸水平属于早产或低出生体重（LBW）组和较高的体重变化s.d.得分足月出生或出生体重正常且s.d.体重变化较小的儿童。评分有最低的血清尿酸levels. CONCLUSION早产和随后的高出生后体重增加率的危险因素增加血清尿酸水平在幼儿期。
BACKGROUNDRecent studies suggest that uric acid plays a causal role in the development of hypertension in relation to birth weight. The aim of the study was to elucidate the effect of prenatal and/or postnatal growth status on serum uric acid levels in children at 3 years of age.METHODSA total of 178 children from the birth cohort at Ewha Womans University Hospital were followed. Anthropometric characteristics, blood pressure, and serum uric acid were measured at 3 years of age.RESULTSThe level of serum uric acid was significantly higher in hypertensive children (3.8 mg/dl) than in nonhypertensive children (3.4 mg/dl). Preterm birth and lower placental weight were the preterm factors significantly associated with increased serum uric acid in early childhood. In addition, current weight, body mass index, and change-in-weight s.d. score from birth to current were also associated with serum uric acid level. Both the first- and fourth-quartile groups for weight and weight gain presented higher levels of serum uric acid. We found that the highest uric acid level belonged to the group of preterm or low birth weight (LBW) and higher change in weight s.d. score. Children who were born at full term or with a normal birth weight and lower change in weight s.d. score had the lowest serum uric acid levels.CONCLUSIONPreterm birth and a subsequent high rate of postnatal weight gain are risk factors for increased serum uric acid levels in early childhood.