Brain structural abnormalities in survivors of pediatric posterior fossa brain tumors: a voxel-based morphometry study using free-form deformation.
Brain structural abnormalities in survivors of pediatric posterior fossa brain tumors: a voxel-based morphometry study using free-form deformation.
复制标题
儿科后颅窝脑肿瘤幸存者的脑结构异常：一项使用自由变形的基于体素的形态测量研究。
DOI：
10.1016/j.neuroimage.2008.04.181
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发表时间：
2008
期刊：
影响因子：
5.7
通讯作者：
Ogg,RobertJ
中科院分区：
文献类型：
--
作者：
Zhang,Yong;Zou,Ping;Mulhern,RaymondK;Butler,RobertW;Laningham,FredH;Ogg,RobertJ
基于体素的形态测量用于比较后颅窝脑肿瘤（PFBT）幸存者的大脑结构与正常同胞对照的大脑结构，以研究疾病或癌症治疗引起的变化。比较了公共领域软件中可用的两种不同的空间归一化方法（自由形式变形（FFD）和离散余弦变换（DCT））的 PFBT 患者归一化的准确性。解剖标志匹配表明，FFD 的空间归一化比 DCT 更准确。对 PFBT 幸存者和同胞对照的 FFD 归一化磁共振图像进行基于体素的形态测量，发现 PFBT 幸存者的丘脑和内嗅皮层灰质密度降低，内囊、下丘脑、胼胝体和枕叶楔骨白质密度降低。这些形态学病变的识别可能有助于定位儿童癌症幸存者中疾病或治疗引起的认知缺陷的神经基质。
Voxel-based morphometry was used to compare brain structure of survivors of posterior fossa brain tumor (PFBT) with that of normal sibling controls to investigate disease- or cancer treatment-induced changes. Two different spatial normalization approaches that are available in public domain software (free-form deformation (FFD) and discrete cosine transform (DCT)) were compared for accuracy of normalization in the PFBT patients. Anatomical landmark matching demonstrated that spatial normalization was more accurate with FFD than with DCT. Voxel-based morphometry of the FFD-normalized magnetic resonance images from PFBT survivors and sibling controls detected reduced gray matter density in the thalamus and entorhinal cortex and reduced white matter density in the internal capsule, hypothalamus, corpus callosum, and cuneus of the occipital lobe in the PFBT survivors. Identification of these morphologic lesions may help localize the neural substrates of disease- or therapy-induced cognitive deficits in survivors of childhood cancer.