Structure-activity relationship studies on CXCR4 antagonists having cyclic pentapeptide scaffolds.
Structure-activity relationship studies on CXCR4 antagonists having cyclic pentapeptide scaffolds.
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DOI：
10.1039/b513145f
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发表时间：
2005-12
影响因子：
3.2
通讯作者：
H. Tamamura;Ai Esaka;Teppei Ogawa;T. Araki;S. Ueda;Zixuan Wang;J. Trent;H. Tsutsumi;H. Masuno;H. Nakashima;N. Yamamoto;S. Peiper;A. Otaka;N. Fujii
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文献类型：
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作者：
H. Tamamura;Ai Esaka;Teppei Ogawa;T. Araki;S. Ueda;Zixuan Wang;J. Trent;H. Tsutsumi;H. Masuno;H. Nakashima;N. Yamamoto;S. Peiper;A. Otaka;N. Fujii
CXCR 4拮抗剂，这是以前发现通过使用环状五肽库的结构-活性关系的研究，进行优化侧链官能团，涉及构象约束的类似物。此外，开发了一种新的引入新药效团的环状五肽先导化合物。
Structure-activity relationship studies on CXCR4 antagonists, which were previously found by using cyclic pentapeptide libraries, were performed to optimize side-chain functional groups, involving conformationally constrained analogues. In addition, a new lead of cyclic pentapeptides with the introduction of a novel pharmacophore was developed.