ROLE OF ABERRANT CRYPT FOCI IN UNDERSTANDING THE PATHOGENESIS OF COLON-CANCER
ROLE OF ABERRANT CRYPT FOCI IN UNDERSTANDING THE PATHOGENESIS OF COLON-CANCER
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DOI：
10.1016/0304-3835(95)03788-x
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发表时间：
1995-06-29
期刊：
影响因子：
9.7
通讯作者：
BIRD, RP
中科院分区：
文献类型：
--
作者：
BIRD, RP
异常隐窝病灶（ACF）存在于致癌物处理的啮齿动物结肠和具有发展该疾病的高风险的人类结肠中。认为ACF是肿瘤前病变。ACF的数量和生长特征的定量已被用于研究结肠癌发生的调节剂。在这篇综述中，提出的例子来支持的概念，ACF是癌前病变，其数量和生长特征（隐窝多样性）在动物结肠的顺序量化可能会提供进一步了解结肠癌的发病机制。它建议，细胞和分子之间的异质性与不同的生长和形态学特征的ACF将是非常宝贵的事件与癌症的发展密切相关的识别。
Aberrant crypt foci (ACF) are present in carcinogen treated rodent colons and in the colons of humans with a high risk for developing the disease. It is proposed that ACF are preneoplastic lesions. Quantification of the number and growth features of ACF has been employed to study modulators of colon carcinogenesis. In this review, examples are presented to support the concept that ACF are preneoplastic lesions and that sequential quantification of their number and growth features (crypt multiplicity) in animal colons may provide further insight into the pathogenesis of colon cancer. It is proposed that cellular and molecular heterogeneity among ACF with different growth and morphologic features will be invaluable in the identification of events critically associated with cancer development.