Decreased biventricular longitudinal strain in patients with systemic sclerosis is mainly caused by pulmonary hypertension and not by systemic sclerosis per se
Decreased biventricular longitudinal strain in patients with systemic sclerosis is mainly caused by pulmonary hypertension and not by systemic sclerosis per se
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DOI：
10.1111/cpf.12561
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发表时间：
2019-05-01
影响因子：
1.8
通讯作者：
Ostenfeld, Ellen
中科院分区：
文献类型：
--
作者：
Lindholm, Anthony;Hesselstrand, Roger;Ostenfeld, Ellen
目的：系统性硬化症（SSc）所致肺动脉高压（PAH）患者死亡率高。SSc组左室（LV）峰值总纵向应变（GLS）降低。目前尚不清楚低GLS是由SSc还是PAH引起的。因此，我们的主要目的是利用具有特征跟踪的心脏磁共振技术，评估伴有和不伴有PAH的SSc患者左室和右室游离壁GLS （RVFW GLS）。次要目的是将GLS与有创平均肺动脉压（mPAP）和肺血管阻力（PVR）联系起来。方法选取SSc患者38例，SSc- pah患者19例，健康对照19例。心内膜和心外膜边界在电影图像（短轴堆栈和三个长轴视图）中勾画，用于体积和应变计算。结果系统性硬化症- pah的LV和RVFW GLS均低于SSc （LV: P = 0中心点01，RV: P = 0.01）
Purpose Patients with pulmonary arterial hypertension (PAH) due to systemic sclerosis (SSc) have high mortality. Left ventricular (LV) peak global longitudinal strain (GLS) is decreased in SSc. It is unknown whether low GLS is due to SSc or PAH. Therefore, our primary aim was to evaluate both LV and right ventricular free wall GLS (RVFW GLS) in SSc, with and without PAH, using cardiac magnetic resonance with feature tracking. Secondary aim was to relate GLS to invasive mean pulmonary arterial pressure (mPAP) and pulmonary vascular resistance (PVR). Methods Thirty-eight patients with SSc, 19 patients with SSc-PAH and 19 healthy controls for comparison, were included. Endocardial and epicardial borders were delineated in cine images (short-axis stack and three long-axis views) for volumetric and strain calculations. Results Systemic sclerosis-PAH had lower LV and RVFW GLS than SSc (LV: P = 0 center dot 01, RV: P