Tooth loss early in life suppresses neurogenesis and synaptophysin expression in the hippocampus and impairs learning in mice
Tooth loss early in life suppresses neurogenesis and synaptophysin expression in the hippocampus and impairs learning in mice
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DOI：
10.1016/j.archoralbio.2016.11.005
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发表时间：
2017-02-01
影响因子：
3
通讯作者：
Iinuma, Mitsuo
中科院分区：
文献类型：
--
作者：
Kubo, Kin-ya;Murabayashi, Chika;Iinuma, Mitsuo
目的：牙齿缺失通过激活应激激素皮质酮引起神经系统改变。在加速衰老的小鼠8（SAMP8）中，早期牙齿脱落加速了海马形态和功能的变化。为了探索由牙齿缺失引起的早期咀嚼功能障碍导致海马功能受损的潜在机制，我们研究了早期牙齿缺失对SAMP 8小鼠在以后生活中海马中血浆皮质酮水平、学习能力、神经发生和突触体素表达的影响。设计：我们研究了牙齿萌出后不久牙齿脱落的影响（1月龄）对血浆皮质酮水平、Morris水迷宫中的学习能力、新生细胞增殖、老年人海马齿状回的存活、分化及海马突触素的表达（8月龄）SAMP8小鼠。早期牙齿脱落的老年小鼠表现出血浆皮质酮水平升高，在Morris水迷宫中表现出海马依赖性学习缺陷，细胞增殖降低，和齿状回中的细胞存活，并抑制海马中的突触体蛋白表达。新生儿的海马齿状回细胞分化，但是，没有受到影响的早期tooth loss.Conclusion：这些研究结果表明，在老年SAMP8小鼠牙齿脱落后不久，牙齿萌出的学习缺陷与抑制的神经发生和突触体素的表达减少导致血浆皮质酮水平增加，长期的牙齿脱落导致认知功能受损的老年人。(C)2016由Elsevier Ltd.出版
Objective: Tooth loss induced neurological alterations through activation of a stress hormone, corticosterone. Age-related hippocampal morphological and functional changes were accelerated by early tooth loss in senescence-accelerated mouse prone 8 (SAMP8). In order to explore the mechanism underlying the impaired hippocampal function resulting from early masticatory dysfunction due to tooth loss, we investigated the effects of early tooth loss on plasma corticosterone levels, learning ability, neurogenesis, and synaptophysin expression in the hippocampus later in life of SAMP8 mice.Design: We examined the effects of tooth loss soon after tooth eruption (1 month of age) on plasma corticosterone levels, learning ability in the Morris water maze, newborn cell proliferation, survival and differentiation in the hippocampal dentate gyrus, and synaptophysin expression in the hippocampus of aged (8 months of age) SAMP8 mice.Results: Aged mice with early tooth loss exhibited increased plasma corticosterone levels, hippocampus-dependent learning deficits in the Morris water maze, decreased cell proliferation, and cell survival in the dentate gyrus, and suppressed synaptophysin expression in the hippocampus. Newborn cell differentiation in the hippocampal dentate gyrus, however, was not affected by early tooth loss.Conclusion: These findings suggest that learning deficits in aged SAMP8 mice with tooth loss soon after tooth eruption are associated with suppressed neurogenesis and decreased synaptophysin expression resulting from increased plasma corticosterone levels, and that long-term tooth loss leads to impaired cognitive function in older age. (C) 2016 Published by Elsevier Ltd.