Association between Attention-Deficit Hyperactivity Disorder in childhood and schizophrenia later in adulthood
Association between Attention-Deficit Hyperactivity Disorder in childhood and schizophrenia later in adulthood
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DOI：
10.1016/j.eurpsy.2013.06.004
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发表时间：
2014-05-01
影响因子：
7.8
通讯作者：
Thomsen, P. H.
中科院分区：
文献类型：
--
作者：
Dalsgaard, S.;Mortensen, P. B.;Thomsen, P. H.
目的：与背景人群比较，评估ADHD儿童青少年成年后精神分裂症的危险性。对象/材料与方法：前瞻性跟踪调查208例青少年ADHD患者。精神分裂症的诊断来自丹麦精神病学中心登记处。ADHD患者与正常人群患精神分裂症的相对风险(RR)以风险比计算。结果：ADHD患者的平均年龄为31.1岁。其中3.8%的病例被诊断为精神分裂症。与一般人群相比，ADHD患者精神分裂症的相对危险度为4.3(95%可信区间为1.9~8.57)。讨论与结论：本次前瞻性随访研究发现ADHD儿童患精神分裂症的风险高于对照组。如果重复，这些结果值得在ADHD患者的临床随访中更多地关注精神分裂症或分裂样精神病可能出现的症状。(C)2013年爱思唯尔·马森公司。版权所有。
Purpose: To estimate the risk of schizophrenia in adulthood among children and adolescents with ADHD compared to the background population.Subjects/materials and methods: Two hundred and eight youths with ADHD (183 boys; 25 girls) were followed prospectively. Diagnoses of schizophrenia were obtained from The Danish Psychiatric Central Register. The relative risk (RR) of schizophrenia for cases with ADHD, compared to the normal population, was calculated as risk ratios. Hazard ratios (HR's) by Cox regression were calculated in the predictor analyses.Results: Mean age for ADHD cases at follow-up was 31.1 years. Schizophrenia diagnoses were given to 3.8% of these cases. Compared to the general population, RR of schizophrenia in cases with ADHD was 4.3 (95% CI 1.9-8.57).Discussion and conclusion: This prospective follow-up study found children with ADHD to be at higher risk of later schizophrenia than controls. If replicated, these results warrant increased focus on the possible emergence symptoms of schizophrenia or schizophreniform psychosis during clinical follow-up of patients with ADHD. (C) 2013 Elsevier Masson SAS. All rights reserved.