Diagnostic performance of positron emission tomography using 11C-methionine in patients with suspected parathyroid adenoma: a meta-analysis
Diagnostic performance of positron emission tomography using 11C-methionine in patients with suspected parathyroid adenoma: a meta-analysis
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DOI：
10.1007/s12020-012-9746-4
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发表时间：
2013-02-01
期刊：
影响因子：
3.7
通讯作者：
Giordano, Alessandro
中科院分区：
文献类型：
--
作者：
Caldarella, Carmelo;Treglia, Giorgio;Giordano, Alessandro
使用C-11-甲硫氨酸（MET-PET）的正电子发射断层扫描在检测甲状旁腺腺瘤中的诊断性能已被几项研究所研究，结果相互矛盾。我们研究的目的是荟萃分析有关这一主题的已发表数据。对截至2012年5月在PubMed/MEDLINE、Scopus和Embase数据库中发表的关于MET-PET在甲状旁腺腺瘤患者中的诊断性能的研究进行了全面的计算机文献检索。没有语言限制。荟萃分析仅纳入至少5例甲状旁腺腺瘤患者接受MET-PET的文章。计算基于每个患者的分析的合并灵敏度和检出率（DR），以评估MET-PET的诊断性能。本荟萃分析纳入了9项研究，包括258例疑似甲状旁腺腺瘤患者。基于每例患者的分析，MET-PET在疑似甲状旁腺腺瘤患者中的合并灵敏度和DR值分别为81%（95%置信区间[95% CI] 74- 86%）和70%（95% CI 62- 77%）。纳入的研究在敏感性和DR的估计上是异质的。我们的荟萃分析表明，MET-PET在疑似甲状旁腺腺瘤患者中是一种敏感和可靠的工具。因此，这种成像方法可能有助于诊断原发性甲状旁腺功能亢进的患者时，常规成像技术是阴性或不确定的定位甲状旁腺腺瘤。
The diagnostic performance of positron emission tomography using C-11-methionine (MET-PET) in detecting parathyroid adenoma has been investigated by several studies with conflicting results. Aim of our study is to meta-analyze published data about this topic. A comprehensive computer literature search of studies published in PubMed/MEDLINE, Scopus and Embase databases through May 2012 and regarding the diagnostic performance of MET-PET in patients with parathyroid adenoma was carried out. No language restriction was used. Only articles in which at least five patients with parathyroid adenoma underwent MET-PET were included in the meta-analysis. Pooled sensitivity and detection rate (DR) on a per patient-based analysis were calculated to assess the diagnostic performance of MET-PET. Nine studies comprising 258 patients with suspected parathyroid adenoma were included in this meta-analysis. Pooled sensitivity and DR values of MET-PET in patients with suspected parathyroid adenoma were 81 % (95 % confidence interval [95 %CI] 74-86 %) and 70 % (95 %CI 62-77 %), respectively, on a per patient-based analysis. The included studies were heterogeneous in their estimate of sensitivity and DR. Our meta-analysis demonstrates that MET-PET is a sensitive and reliable tool in patients with suspected parathyroid adenoma. Thus, this imaging method could be helpful in patients with diagnosis of primary hyperparathyroidism when conventional imaging techniques are negative or inconclusive in localizing parathyroid adenoma.