Redirecting RNA splicing by SMAD3 turns TGF-β into a tumor promoter.
Redirecting RNA splicing by SMAD3 turns TGF-β into a tumor promoter.
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SMAD3 重定向 RNA 剪接将 TGF-β 转变为肿瘤促进剂。
DOI：
10.1080/23723556.2016.1265699
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发表时间：
2017
影响因子：
2.1
通讯作者：
Zhang,YingE
中科院分区：
文献类型：
--
作者：
Tripathi,Veenu;Zhang,YingE
转化生长因子β（TGF-β）是一种众所周知的正常上皮细胞生长抑制剂，但它也由实体瘤分泌，以促进癌症进展。我们最近发现的SMAD 3-PCBP 1复合物具有直接的RNA结合特性，揭示了这种转换是如何通过控制前mRNA剪接模式来实现的。
Transforming growth factor β (TGF-β) is a well-known growth inhibitor of normal epithelial cells, but it is also secreted by solid tumors to promote cancer progression. Our recent discovery of SMAD3-PCBP1 complex with direct RNA-binding properties has shed light on how this conversion is implemented by controlling pre-mRNA splicing patterns.