Mini-dose glucagon rescue for mild hypoglycaemia in children with type 1 diabetes: The Brisbane experience
Mini-dose glucagon rescue for mild hypoglycaemia in children with type 1 diabetes: The Brisbane experience
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DOI：
10.1111/j.1440-1754.2006.00807.x
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发表时间：
2006-03-01
影响因子：
1.7
通讯作者：
Cotterill, AM
中科院分区：
文献类型：
--
作者：
Hartley, M;Thomsett, MJ;Cotterill, AM
目的：评价使用胰岛素注射器的小剂量胰升糖素在1型糖尿病儿童轻度或即将发生的低血糖中的应用。方法：收集2002-2004年在布里斯班母亲医院昆士兰糖尿病中心的儿科糖尿病诊所就诊的患者的数据，此前制定了一项新的家庭管理方案，用于治疗与不能或拒绝口服碳水化合物相关的轻微或即将发生的低血糖。该方案建议对2岁或2岁以下的儿童使用胰岛素注射器皮下注射胰高血糖素，剂量为两个单位(20微克)，对于年龄较大的儿童，每年注射一个单位，最大剂量为15单位(150微克)，如果血糖在20分钟内没有上升，则额外给予双倍剂量。结果：在两年的时间里，25名儿童总共接受了38次小剂量高血糖素治疗。有20次(53%)的反复低血糖需要额外的剂量。38例患儿中32例(84%)可在家中接受治疗，仅6例(16%)患儿需要住院治疗。结论：我们的研究证实，小剂量胰岛素注射器皮下注射小剂量胰高血糖素是治疗1型糖尿病儿童因胃肠炎或食物拒绝引起的轻度或即将发生的低血糖的简单、实用和有效的家庭治疗方法。
Objectives: To evaluate the use of small doses of glucagon using an insulin syringe in mild or impending hypoglycaemia in children with type 1 diabetes.Methods: Data were collected from patients attending the Paediatric Diabetes Clinic at the Queensland Diabetes Centre at the Mater Hospital, Brisbane in 2002-2004 following the institution of a new protocol for home management of mild or impending hypoglycaemia associated with inability or refusal to take oral carbohydrate. The protocol recommended the use of subcutaneous injections of glucagon using insulin syringes at a dose of two ' units ' (20 mu g) in children 2 years of age or younger, and for older children one unit per year of age up to a maximum of 15 units (150 mu g), with an additional doubled dose given if the blood glucose had not increased in 20 min.Results: Over a 2-year period, 25 children were treated with mini-dose glucagon on a total of 38 occasions. Additional doses were required for recurring hypoglycaemia on 20 (53%) occasions. The child could be managed at home on 32 (84%) of these 38 occasions, with only 6 (16%) children needing hospital treatment.Conclusions: Our study confirmed that small doses of glucagon given subcutaneously with an insulin syringe is a simple, practical and effective home treatment of mild or impending hypoglycaemia due to gastroenteritis or food refusal in children with type 1 diabetes.