15N Tracer Investigations of the Physiological Availability of Urea Nitrogen in Mother's Milk
15N Tracer Investigations of the Physiological Availability of Urea Nitrogen in Mother's Milk
复制标题
母乳中尿素氮生理有效性的 15N 示踪剂研究
DOI：
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发表时间：
1986
期刊：
影响因子：
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通讯作者：
K. Wutzke
中科院分区：
文献类型：
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作者：
W. Heine;M. Tiess;K. Wutzke
摘要。在使用[15 N]2尿素的示踪研究中，对母乳中尿素的生理利用率进行了研究，涉及22名婴儿。16名受试者通过发射光谱法测定血清蛋白中过量的15 N，建立了15 N掺入体内蛋白的方法。母乳中的尿素氮合成了2%到3.6%的血清蛋白.在6名婴儿的15 N平衡的进一步研究中，经口多次和单次脉冲标记[15 N]2尿素后，15 N的肾脏排泄占给药剂量的60%。十分之三-2.5%经粪便排泄。15 N在蛋白质池中的保留率在16.7%和61.4%之间变化
ABSTRACT. The physiological availability of urea in mother's milk was investigated in tracer studies using [15N]2 urea and involving 22 infants. The incorporation of 15N into the body protein was established in 16 subjects by emission spectrophotometrical determination of the 15N excess in the serum protein. Between 2 % and 3.6 % of the serum protein is synthesized from the urea nitrogen in mother's milk. In further studies on the 15N balance in 6 infants, renal excretion of 15N after oral multiple and single impulse labelling with [15N]2 urea constituted 60 % of the dose administered. Three‐tenths–2.5 % was excreted in the feces. The retention of 15N in the protein pool varied between 16.7 and 61.4 %