INTERLEUKIN-8 INHIBITS THE INDUCTION OF NITRIC-OXIDE SYNTHASE IN RAT PERITONEAL NEUTROPHILS
INTERLEUKIN-8 INHIBITS THE INDUCTION OF NITRIC-OXIDE SYNTHASE IN RAT PERITONEAL NEUTROPHILS
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DOI：
10.1016/0006-291x(92)90800-z
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发表时间：
1992-07-31
影响因子：
3.1
通讯作者：
MONCADA, S
中科院分区：
文献类型：
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作者：
MCCALL, TB;PALMER, RMJ;MONCADA, S
研究了白细胞介素8(IL-8)和白三烯B4(LTB-4)对体外培养的大鼠腹膜中性粒细胞(PMN)诱生一氧化氮合酶(NO)的影响。IL-8对钙非依赖性NO合酶的诱导有浓度依赖性抑制作用，而LTB-4无此作用。IL-8的作用不是由于该酶的一种抑制剂的合成。这些发现表明，细胞因子对一氧化氮合酶的诱导具有复杂的调控作用。
The effect of interleukin (IL)-8 and leukotriene B 4 (LTB 4) on the induction of nitric oxide (NO) synthase in rat peritoneal neutrophils (PMN) ex vivo was studied. IL-8, but not LTB 4, caused concentration-dependent inhibition of the induction of a Ca 2+-independent NO synthase ex vivo. The effect of IL-8 was not attributable to the synthesis of an inhibitor of this enzyme. These findings suggest complex regulatory control of the induction of NO synthase by cytokines.