Contributions of Low and High Spatial Frequency Processing to Impaired Object Recognition Circuitry in Schizophrenia
Contributions of Low and High Spatial Frequency Processing to Impaired Object Recognition Circuitry in Schizophrenia
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DOI：
10.1093/cercor/bhs169
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发表时间：
2013-08-01
期刊：
影响因子：
3.7
通讯作者：
Butler, Pamela D.
中科院分区：
文献类型：
--
作者：
Calderone, Daniel J.;Hoptman, Matthew J.;Butler, Pamela D.
精神分裂症患者表现出认知和感觉障碍，对象识别缺陷与感觉缺陷有关。物体识别的框架和填充模型假设低空间频率(LSF)信息快速到达前额叶皮质(PFC)，并产生物体的大致形状，该物体反馈到腹侧颞叶皮质以辅助物体识别。精神分裂症患者的视觉功能障碍提示LSF信息优先丢失。本研究使用功能磁共振成像(FMRI)和静息状态功能连接(RSFC)来研究视觉缺陷对精神分裂症患者物体框架电路受损的贡献。向参与者展示的对象刺激是完整的或仅包含LSF或高空间频率(HSF)信息。对于对照组，fMRI显示在楔前、颞上、内侧和背外侧PFC区优先激活LSF信息，而患者表现出对HSF信息的偏好或没有偏好。RSFC显示患者早期视觉区域和PFC之间缺乏连接。这些结果表明，精神分裂症患者在物体识别过程中对LSF信息的处理受损，患者反而表现出对HSF信息的处理增加。这与精神分裂症患者偏爱局部而不是全局视觉信息的发现是一致的。
Patients with schizophrenia exhibit cognitive and sensory impairment, and object recognition deficits have been linked to sensory deficits. The frame and fill model of object recognition posits that low spatial frequency (LSF) information rapidly reaches the prefrontal cortex (PFC) and creates a general shape of an object that feeds back to the ventral temporal cortex to assist object recognition. Visual dysfunction findings in schizophrenia suggest a preferential loss of LSF information. This study used functional magnetic resonance imaging (fMRI) and resting state functional connectivity (RSFC) to investigate the contribution of visual deficits to impaired object framing circuitry in schizophrenia. Participants were shown object stimuli that were intact or contained only LSF or high spatial frequency (HSF) information. For controls, fMRI revealed preferential activation to LSF information in precuneus, superior temporal, and medial and dorsolateral PFC areas, whereas patients showed a preference for HSF information or no preference. RSFC revealed a lack of connectivity between early visual areas and PFC for patients. These results demonstrate impaired processing of LSF information during object recognition in schizophrenia, with patients instead displaying increased processing of HSF information. This is consistent with findings of a preference for local over global visual information in schizophrenia.