The effect of ferric-nitrilotriacetic acid on the profile of polyunsaturated fatty acids in the kidney and liver of rats
The effect of ferric-nitrilotriacetic acid on the profile of polyunsaturated fatty acids in the kidney and liver of rats
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DOI：
10.1016/s0378-4274(01)00372-1
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发表时间：
2001-09-15
影响因子：
3.5
通讯作者：
Dessi, MA
中科院分区：
文献类型：
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作者：
Deiana, M;Aruoma, OI;Dessi, MA
腹膜内注射铁络合物，次氮基三乙酸铁（Fe-NTA），诱导体内与氧化损伤相关的近端肾小管损伤。Fe-NTA诱导了几种多不饱和脂肪酸（PUFA）的时间依赖性降低，以及共轭二烯值增加和α-生育酚和谷胱甘肽的细胞水平降低。在最大可检测氧化时（3 h），注射亚致死剂量的Fe-NTA后，肾脏中几种脂肪酸的峰值明显低于对照组，特别是20：5（二十碳五烯酸）（36%）、22：6（二十二碳六烯酸）（30%）、20：3 n6（二十碳三烯酸）（30%）和20：4（花生四烯酸）（28%）。较少的脂肪酸显示其在肝脏中的残留值降低。20：5减少了45%，18：3 n3和18：3 n6分别减少了35%。PUFAs的分布对由于Fe-NTA引起的氧化损伤敏感，这可以作为氧化生物标志物模型找到应用。(C)2001爱思唯尔科学爱尔兰有限公司保留所有权利。
Intraperitoneal injection of the iron-complex, ferric-nitrilotriacetate (Fe-NTA), induces renal proximal tubular damage associated with oxidative damage in vivo. Fe-NTA induced a time-dependent decrease of several polyunsaturated fatty acids (PUFA), together with increased conjugated diene values and decreased cellular levels of alpha -tocopherol and glutathione. At the time of maximum detectable oxidation (3 h), after the injection of a sublethal dose of Fe-NTA there were clear reductions in the peak values over the controls for several fatty acids notably, 20:5 (eicosapentaenoic acid) (36%), 22:6 (docosahexanoic acid) (30%), 20:3 n6 (eicosatrienoic acid) (30%) and 20:4 (arachidonic acid) (28%) in the kidney. Fewer fatty acids showed a reduction in their residual values in the liver. 20:5 was reduced by 45% and for the 18:3 n3 and 18:3 n6, reductions of 35%, respectively. The profile of PUFAs is sensitive to the oxidative damage due to Fe-NTA and this may find applications as oxidative biomarker model. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.