Immunologic disease and fetal death.
Immunologic disease and fetal death.
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免疫疾病和胎儿死亡。
DOI：
10.1097/00003081-198706000-00009
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发表时间：
1987
影响因子：
1.5
通讯作者：
Branch,DW
中科院分区：
文献类型：
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作者：
Branch,DW
GSZS生殖在免疫学上是独特的。在正常妊娠中，母体免疫系统在保护母体免受外来生物入侵方面功能良好，但它不能排斥抗原性外来胎儿和胎盘。这个悖论多年来一直困扰着研究人员。鉴于围绕着孕体的免疫学接受的神秘性，免疫功能障碍被归咎于某些患者的妊娠失败也就不足为奇了。从本质上讲，流产的假定免疫学原因分为三类：（1）同种免疫：正常母体妊娠耐受性的发展失败，随后出现孕体的免疫排斥，（2）同种免疫 *：母体针对母胎红细胞抗原的抗体破坏胎儿红细胞，和（3）自身免疫：针对母胎抗原的母体自身抗体损伤胎儿或子宫胎盘组织。同种免疫-介质-
GSZS reproduction is immuno-logically unique. In normal preg-nancy the maternal immune system func-tions perfectly well in protecting the mother from invasion by foreign organisms, yet it fails to reject the antigenically foreign fetus and placenta. This paradox has intrigued investigators for years. In light of the mystery surrounding the immunological acceptance of the conceptus, it should come as no surprise that immune dysfunction has been blamed for preg-nancy loss in some patients. Essentially, the supposed immunologic causes of pregnancy loss fall into three categories:(1) alloimmune: the failure of the develop-ment of the normal maternal tolerance to pregnancy, with subsequent immunologic rejection of the conceptus,(2) isoimmune*: destruction of fetal erythrocytes by maternal antibodies directed against fetopaternal red cell antigens, and (3) autoimmune: damage offetal or uteroplacental tissues by maternal autoantibodies directed against maternofetal antigens. Alloimmune-medi-