The Exocyst Complex in Health and Disease.
The Exocyst Complex in Health and Disease.
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DOI：
10.3389/fcell.2016.00024
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发表时间：
2016
影响因子：
5.5
通讯作者：
Jourdain I
中科院分区：
文献类型：
--
作者：
Martin-Urdiroz M;Deeks MJ;Horton CG;Dawe HR;Jourdain I
胞吐作用涉及细胞内分泌囊泡与质膜的融合，从而将整合的膜蛋白递送到细胞表面并将物质释放到细胞外空间中。重要的是，胞吐作用还为膜延伸提供了脂质部分的来源。分泌囊泡在与质膜对接和融合之前的束缚是由外囊复合物介导的，外囊复合物是一种进化上保守的八聚体蛋白质复合物。最近的研究表明，外囊复合物也参与其他细胞内的过程，除了分泌。从真菌到植物，从神经元到纤毛，这些不同的功能似乎都在朝着确定膜生长方向的方向发展。在这篇综述中，我们总结了目前的知识外囊功能的细胞极性，信号和细胞间通讯，并讨论了植物和动物的健康和疾病的影响。
Exocytosis involves the fusion of intracellular secretory vesicles with the plasma membrane, thereby delivering integral membrane proteins to the cell surface and releasing material into the extracellular space. Importantly, exocytosis also provides a source of lipid moieties for membrane extension. The tethering of the secretory vesicle before docking and fusion with the plasma membrane is mediated by the exocyst complex, an evolutionary conserved octameric complex of proteins. Recent findings indicate that the exocyst complex also takes part in other intra-cellular processes besides secretion. These various functions seem to converge toward defining a direction of membrane growth in a range of systems from fungi to plants and from neurons to cilia. In this review we summarize the current knowledge of exocyst function in cell polarity, signaling and cell-cell communication and discuss implications for plant and animal health and disease.