SYNTHETIC AND NATURAL ESCHERICHIA-COLI FREE LIPID-A EXPRESS IDENTICAL ENDOTOXIC ACTIVITIES
SYNTHETIC AND NATURAL ESCHERICHIA-COLI FREE LIPID-A EXPRESS IDENTICAL ENDOTOXIC ACTIVITIES
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DOI：
10.1111/j.1432-1033.1985.tb08798.x
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发表时间：
1985-01-01
期刊：
影响因子：
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通讯作者：
SHIBA, T
中科院分区：
文献类型：
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作者：
GALANOS, C;LUDERITZ, O;SHIBA, T
最近化学合成的大肠杆菌脂质A和大肠杆菌天然游离脂质A在以下测试系统中比较了它们的内毒性活性：致死毒性、热原性、局部Shwartzman反应性、鲎变形细胞裂解物凝胶化能力、肿瘤坏死活性、B细胞有丝分裂性、巨噬细胞中前列腺素合成的诱导和抗原特异性。合成和天然游离脂质 A 表现出相同的活性，并且在所有测试中都无法区分。
The recently chemically synthesized E. coli lipid A and the natural free lipid A of E. coli were compared with respect to their endotoxic activities in the following test systems: lethal toxicity, pyrogenicity, local Shwartzman reactivity, Limulus amoebocyte lysate gelation capacity, tumor nectrotizing activity, B cell mitogenicity, induction of prostaglandin synthesis in macrophages, and antigenic specificity. Synthetic and natural free lipid A exhibited identical activities and were indistinguishable in all tests.