SUMOylation Regulation of Retina Development and Functions.
SUMOylation Regulation of Retina Development and Functions.
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视网膜发育和功能的 SUMOylation 调节。
DOI：
10.2174/1566524016666161128115453
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发表时间：
2016-10
影响因子：
2.5
通讯作者：
DW Li
中科院分区：
文献类型：
--
作者：
Zhang L;DW Li
脊椎动物视网膜的结构和发育机制高度保守。视网膜发生过程中最独特的事件之一是从多潜能的视网膜前体细胞在时间和空间上产生七种类型的视网膜细胞。SUMO化在通过调节基因表达和蛋白质功能多样性来调节这一过程中的重要性和普遍性已越来越受到人们的重视。本文综述了SUMO化在视网膜发育中的生物学意义，研究了SUMO化如何平衡视网膜前体细胞的增殖和细胞周期退出，最后讨论了通过调节各种转录因子来调节不同视网膜神经元和光感受器的分子机制。SUMO化在正常视网膜功能中的潜在作用通过小鼠视网膜中SUMO化机制的关键成分的丰富表达来说明，也被神经节细胞中神经递质受体上高度保守的SUMO化位点所证明。
The structure and developmental mechanisms of vertebrate retina are highly conserved. One of the most distinctive events during retinogenesis is the temporally and spatially generation of seven types of retinal cells from the multipotent retinal progenitor cells. The importance and prevalence of SUMOylation in regulation of this process through modulation of gene expression and protein function diversity have been increasingly appreciated. Here, we review the biological significance of SUMOylation in retina development, examine how SUMOylation balances the proliferation and cell cycle exit of retinal progenitor cells, and finally discuss the molecular mechanisms mediating the specification of different retina neurons and photoreceptors through modulation of various transcription factors. The potential role of SUMOylation in normal retina function is illustrated by the abundant expression of key components of SUMOylation machinery in mouse retina, and is also exemplified by the highly conserved SUMOylation site on neurotransmission receptors in ganglion cells.