Assessment of the interaction of heritability of volume load and left ventricular mass: the HyperGEN offspring study
Assessment of the interaction of heritability of volume load and left ventricular mass: the HyperGEN offspring study
复制标题
DOI：
10.1097/hjh.0b013e328126851e
复制
发表时间：
2007-07-01
影响因子：
4.9
通讯作者：
Arnett, Donna K.
中科院分区：
文献类型：
--
作者：
de Simone, Giovanni;Tang, Weihong;Arnett, Donna K.
背景左心室质量（LVM）与容积负荷的关系比与压力负荷的关系更密切。我们评估了LVM的部分遗传能力是否可以用卒中量遗传来解释。方法对来自HyperGEN研究的527个至少有两个亲属的家庭（51%非裔美国人，43%男性，44%肥胖，53%高血压）的LVM、SV和外周阻力进行超声心动图测量。纳入了1792名没有流行心血管疾病、糖尿病和肾衰竭的受试者。使用方差成分法（SOLAR）估计种族特异性遗传相关性。结果调整年龄、性别、种族、野心、收缩压、抗高血压药物数量和体重指数后，LVM和SV存在显著的遗传相关性(非裔美国人rho(g)=0.93，白种人rho(g)= 0.70；P < 0.0001)。尿钠+排泄或血清肌酐对这些相关性没有影响。调整协变量后，LVM的遗传力更大(非裔美国人h(2)=0.46，白种人h(2)= 0.47；P < 0.0001)高于SV组(h(2)在非裔美国人中=0.18，在白种人中= 0.29；P < 0.02)。LVM的遗传力在非裔美国人中略有下降（h(2)=0.34），但在白种人中没有下降(h(2)=0.45；当SV加入协变量时，P < 0.0001)。在模型中加入LVM后，非洲裔美国人的SV遗传力几乎消失（h(2)=0.04， P=不显著），而高加索人的SV遗传力略有降低（h(2)=0.20, P < 0.005）。结论LVM和SV具有共同的遗传谱，但相互影响不大。LVM的变异性对SV的计算遗传力有一定影响，特别是在非洲裔美国人中，而遗传体积负荷在决定LVM变异性中的作用仅在非洲裔美国人中是适度的。
Background Left ventricular mass (LVM) is more closely associated with volume load than pressure load. We assessed whether part of the genetic heritability of LVM can be explained by stroke volume (SV) inheritance.Methods Echocardiographic LVM, SV and peripheral resistance were measured in 527 families with at least two relatives from the HyperGEN study (51% African-American, 43% men, 44% obese, 53% hypertensive). Included were 1792 subjects without prevalent cardiovascular disease, diabetes and renal failure. Ethnic-specific genetic correlations were estimated using a variance components procedure ( SOLAR).Results Significant genetic correlations existed between LVM and SV after adjusting for age, sex, race, field center, systolic blood pressure, number of antihypertensive medications, and body mass index (rho(g)=0.93 in African-Americans and 0.70 in Caucasians; both P < 0.0001). Urinary Na+ excretion or serum creatinine did not influence these correlations. After adjusting for covariates, heritability of LVM was greater (h(2)=0.46 in African-Americans and 0.47 in Caucasians; both P < 0.0001) than that for SV (h(2)=0.18 in African-Americans and 0.29 in Caucasians; both P < 0.02). Heritability of LVM slightly decreased in African-Americans (h(2)=0.34), but not in Caucasians (h(2)=0.45; both P < 0.0001) when SV was added to covariates. Heritability of SV almost disappeared by addition of LVM into the model in African-Americans (h(2)=0.04, P=not significant), whereas it was slightly reduced in Caucasians (h(2)=0.20, P < 0.005).Conclusion LVM and SV share a common genetic profile, but with only a modest reciprocal influence. Variability of LVM has some effect on calculated heritability of SV, especially in African-Americans, whereas the role of heritable volume load in determining the variability of LVM was modest only in African-Americans.