GSTM1, GSTT1 null variants, and GPX1 single nucleotide polymorphism are not associated with bladder cancer risk in Egypt.
GSTM1, GSTT1 null variants, and GPX1 single nucleotide polymorphism are not associated with bladder cancer risk in Egypt.
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DOI：
10.1158/1055-9965.epi-10-1306
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发表时间：
2011-07
期刊：
影响因子：
--
通讯作者：
Loffredo C
中科院分区：
文献类型：
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作者：
Goerlitz D;El Daly M;Abdel-Hamid M;Saleh DA;Goldman L;El Kafrawy S;Hifnawy T;Ezzat S;Abdel-Aziz MA;Zaghloul MS;Ali SR;Khaled H;Amr S;Zheng YL;Mikhail N;Loffredo C
膀胱癌是埃及最常见的男性恶性肿瘤，主要由尿路上皮细胞（UC）和鳞状细胞（SCC）癌组成，无论地理区域如何，男性和女性之间的发病率存在差异。烟草烟雾暴露和血吸虫（SH）感染和GSTM1，GSTT1和GPX1基因型的存在，作为活性氧化物质（ROS）的致癌作用的调节剂，被假设为修改膀胱癌的风险，并可能解释这些性别差异。我们评估了膀胱癌风险与GSTM1，GSTT1和GPX1基因功能多态性之间的关联，在埃及的625例病例和626例匹配的基于人群的对照中，并评估了这些候选基因与环境暴露（如吸烟和SH）之间的潜在相互作用。我们分别分析了UC和SCC的风险。这些功能多态性与膀胱癌风险无显著相关。在这一人群中，基因型与吸烟或SH之间没有显著的相互作用，也没有检测到男性和女性之间的基因型风险有任何差异。我们的研究结果表明，GSTM1，GSTT1和GPX1的常见遗传变异与膀胱癌风险总体上无关，并且众所周知的环境风险因素，如吸烟和SH不会与这些基因相互作用以调节风险。我们的数据表明，GSTM1，GSTT1和GPX1的常见遗传变异与膀胱癌风险无关。
Bladder cancer is the most common male malignancy in Egypt, consists predominantly of urothelial cell (UC) and squamous cell (SCC) carcinoma, and disparities in incidence exist between men and women regardless of geographic region. Tobacco smoke exposure and Schistosoma haematobium (SH) infection and the presence of GSTM1, GSTT1, and GPX1 genotypes, as modulators of the carcinogenic effect of reactive oxidative species (ROS), were hypothesized to modify bladder cancer risk and possibly explain these gender differences. We evaluated the association between bladder cancer risk and functional polymorphisms in the GSTM1, GSTT1, and GPX1 genes in 625 cases and 626 matched population-based controls in Egypt, and assessed for potential interactions between these candidate genes and environmental exposures such as smoking and SH. We analyzed the risk for UC and SCC separately. None of these functional polymorphisms were significantly associated with bladder cancer risk. There were no significant interactions between genotypes and smoking or SH in this population, nor was any difference detected in genotypic risk between men and women. Our findings suggest that common genetic variations in GSTM1, GSTT1, and GPX1 are not associated with bladder cancer risk overall, and that well known environmental risk factors, such as smoking and SH do not interact with these genes to modulate the risk. Our data indicate that common genetic variations in GSTM1, GSTT1, and GPX1 were not associated with bladder cancer risk.