Functional magnetic resonance imaging of proactive interference during spoken cued recall
Functional magnetic resonance imaging of proactive interference during spoken cued recall
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DOI：
10.1006/nimg.2002.1229
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发表时间：
2002-10-01
期刊：
影响因子：
5.7
通讯作者：
Dolan, RJ
中科院分区：
文献类型：
--
作者：
Henson, RNA;Shallice, T;Dolan, RJ
虽然额叶皮质的损伤会增加对先前建立的但不相关的记忆的干扰（“主动干扰”）的易感性，但由于损伤通常很大且异质性，因此很难确定该问题的具体区域。我们使用事件相关功能磁共振成像来研究健康志愿者执行“AB-AC”配对关联线索回忆范式时的主动干扰。在研究中，参与者有意编码语义相关的视觉词对，这些词对被改变三次（高干扰），重复三次（低干扰），或者只出现一次。在测试中，参与者看到每对单词的第一个单词，并试图回忆起研究阶段中与之相关的最近的单词。为了克服由语音相关的头部运动引起的图像伪影问题，我们在图像采集之间的间隙提示语音。左侧额下皮层和双侧额极皮层在研究和测试中均表现出干扰效应。然而，这些区域的反应模式有所不同。左侧下额区主要表现为低干扰相关的反应减少，而额极区主要表现为高干扰相关的反应增加。当在测试中分析错误和正确的试验时，在右背外侧前额叶皮层观察到与高干扰相关的额外激活。这些数据表明，在提示回忆过程中，前额叶皮层的不同区域在存在主动干扰的情况下具有不同的功能。， (C) 2002 Elsevier Science （USA）。
Though lesions to frontal cortex can increase susceptibility to interference from previously established but irrelevant memories ("proactive interference"), the specific regions underlying this problem are difficult to determine because the lesions are typically large and heterogeneous. We used event-related functional magnetic resonance imaging to investigate proactive interference in healthy volunteers performing an "AB-AC" paired-associate cued-recall paradigm. At Study, participants intentionally encoded semantically related visual word pairs, which were changed three times (high interference), repeated three times (low interference), or presented only once. At Test, participants were presented with the first word of each pair and attempted to recall its most recent associate from the Study phase. To overcome the problem of image artifacts caused by speech-related head motion, we cued speech during a gap between image acquisitions. Regions in left inferior frontal cortex and bilateral frontopolar cortex showed interference effects during both Study and Test. The pattern of responses in these regions differed, however. Left inferior frontal regions showed mainly reduced responses associated with low interference, whereas frontopolar regions showed mainly increased responses associated with high interference. When incorrect as well as correct trials were analyzed at Test, additional activation associated with high interference was observed in right dorsolateral prefrontal cortex. These data suggest that distinct regions within prefrontal cortex subserve different functions in the presence of proactive interference during cued recall., (C) 2002 Elsevier Science (USA).