Rapamycin prevents Concanavalin A‐induced liver injury by inhibiting lymphocyte activation
Rapamycin prevents Concanavalin A‐induced liver injury by inhibiting lymphocyte activation
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DOI：
10.1111/j.1440-1746.2009.05866.x
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发表时间：
2009-08
影响因子：
4.1
通讯作者：
Yuanqing Zhang;Xiang Xiao;Xianchang Li;Haiming Wei
中科院分区：
文献类型：
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作者：
Yuanqing Zhang;Xiang Xiao;Xianchang Li;Haiming Wei
背景与目的：刀豆蛋白A(ConA)诱导的肝损伤是研究免疫性肝损伤病理生理机制的常用模型。雷帕霉素是一种有效的免疫抑制剂，广泛用于预防免疫激活和移植排斥反应。然而，RAPA对ConA所致肝损伤的影响尚未得到仔细研究。在本研究中，我们观察了RAPA对ConA所致肝损伤的影响。
Background and Aims: Liver injury induced by Concanavalin A (Con A) is often used as a model to study the pathophysiology of immune mediated liver injury. Rapamycin (Rapa) is an effective immunosuppressant widely used for preventing immune activation and transplant rejection. However, the effect of Rapa on liver injury caused by Con A has not been carefully examined. In the present study, we examined the effect of Rapa on liver injury caused by Con A.