Consequences of Perinatal Cannabis Exposure.
Consequences of Perinatal Cannabis Exposure.
复制标题
围产期大麻暴露的后果。
DOI：
10.1016/j.tins.2019.08.010
复制
发表时间：
2019
影响因子：
15.9
通讯作者：
Manzoni,OlivierJJ
中科院分区：
文献类型：
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作者：
Scheyer,AndrewF;Melis,Miriam;Trezza,Viviana;Manzoni,OlivierJJ
围产期接触大麻会给受影响的后代带来各种重大后果。随着大麻合法化和接受程度的扩大，围产期接触大麻造成的有害后果的发生率可能会增加。 因此，强调大麻暴露对产前和产后发育的直接和长期影响至关重要。在这里，我们发现了围产期大麻素暴露（使用合成大麻素或大麻植物活性成分）的动物模型中神经元学习灵活性（突触可塑性）和表观遗传失调的持久变化，以及社会行为和执行功能的显着改变。这些发现得到了流行病学数据的支持，这些数据表明在怀孕期间接触大麻的人类后代在整个一生中都有类似的行为结果。此外，我们指出了有关围产期大麻暴露的准确建模以及未来研究中性别和年龄依赖性结果测量的必要性的重要挥之不去的问题。
Cannabis exposure during the perinatal period results in varied and significant consequences in affected offspring. The prevalence of detrimental outcomes of perinatal cannabis exposure is likely to increase in tandem with the broadening of legalization and acceptance of the drug. As such, it is crucial to highlight the immediate and protracted consequences of cannabis exposure on pre- and postnatal development. Here, we identify lasting changes in neurons' learning flexibility (synaptic plasticity) and epigenetic misregulation in animal models of perinatal cannabinoid exposure (using synthetic cannabinoids or active components of the cannabis plant), in addition to significant alterations in social behavior and executive functions. These findings are supported by epidemiological data indicating similar behavioral outcomes throughout life in human offspring exposed to cannabis during pregnancy. Further, we indicate important lingering questions regarding accurate modeling of perinatal cannabis exposure as well as the need for sex- and age-dependent outcome measures in future studies.