Pathogenesis of osteopetrosis in the microphthalmic mouse: reduced bone resorption.
Pathogenesis of osteopetrosis in the microphthalmic mouse: reduced bone resorption.
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DOI：
10.1002/aja.1001490209
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发表时间：
1977-06
期刊：
影响因子：
--
通讯作者：
S. Marks,
中科院分区：
文献类型：
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作者：
S. Marks,
在小鼠体内观察注射甲状旁腺提取物刺激的骨吸收，以掺入~3H-脯氨酸后骨释放~3H的速率为指标。这些遗传了骨化症的小鼠的骨吸收不到正常文学家的10%。放射自显影证实小鼠放射性骨基质的去除和骨生长减少。这些小鼠因PTE而升高血清钙浓度的能力也降低了。这些结果，即小眼症小鼠的骨吸收减少，与疾病的发病机制和治疗有关。
Bone resorption, stimulated by injection of parathyroid extract, was measured in vivo in microphthalmic mice as the rate of release of 3H from bone after incorporation of 3H-proline. Bone resorption in these mice, which inherit osteopetrosis, was less than 10% of the in normal litermates. Autoradiography confirmed the reduction in removal of radioactive bone matrix and in bone growth in microphthalmic mice. The ability of these mice to raise the serum calcium concentration in response to PTE was also reduced. These results, that bone resorption is reduced in microphthalmic mice, are discussed in relation to the pathogenesis and cure of the disease.