Editorial of Virtual Special Issue on Progress in Medicinal Chemistry.
Editorial of Virtual Special Issue on Progress in Medicinal Chemistry.
复制标题
关于药物化学进展的虚拟特刊的社论。
DOI：
10.1016/j.apsb.2016.08.002
复制
发表时间：
2016
期刊：
影响因子：
--
通讯作者：
Guan,Xiangming
中科院分区：
文献类型：
--
作者：
Guan,Xiangming
药物靶点鉴定是开发有效治疗药物的关键步骤。在这篇文章中，我们介绍了一些已经证实的和潜在的药物发现靶点的现状，这些靶点用于开发治疗癌症、炎症、心血管疾病、神经退行性疾病、艾滋病毒和甲型流感病毒的药物。我感谢我的同事们的合作和努力，他们在百忙之中抽出时间对这个问题作出贡献。同时，我谨代表所有的撰稿人，感谢该杂志为我们提供了一个机会来分享我们对这些有趣话题的看法，并希望这一问题将使研究科学家在与这些话题相关的研究中受益。第一篇文章来自王炳和和他的同事，描述了最近在制造药物上可接受的治疗性硫化氢的前药方面的进展。近年来，人们对包括一氧化氮（NO）、一氧化碳（CO）和硫化氢在内的气体信号分子的兴趣显著增加。这些分子是内源性产生的，在哺乳动物中起着关键的调节作用。当然，它们也是开发治疗方法的绝佳靶点。开发气体分子作为治疗方法的一个关键挑战是其安全性和可控制的递送。前药是应对这一挑战的一种非常有效的方法。癌症转移是发病率和死亡率的主要原因，约90%的癌症死亡是由癌症转移引起的。尽管近年来癌症存活率有了显著的提高，但这种提高主要是由于早期诊断和肿瘤生长抑制。癌症转移的治疗进展有限。关向明综述了转移过程，重点介绍了转移的四个基本步骤（脱离、迁移、侵袭和粘附）、相关生化参数以及预防和抑制转移的靶点。
Drug target identification is a key step in the development of effective therapeutic agents. In this issue, we present the current status of some validated and potential targets in drug discovery for developing therapeutic agents for the treatment of cancer, inflammation, cardiovascular diseases, neurodegenerative diseases, HIV, and influenza A virus. I am indebted to my colleagues for their cooperation and efforts to find time from their busy schedule to contribute to this issue. Also I would like to thank, on behalf of all the contributors, the journal for providing us an opportunity to share our thoughts on these interesting topics and hope this issue will benefit research scientists in their pursues related to these topics.The first article, from Binghe Wang and colleagues, describes the recent development in making prodrugs of pharmaceutically acceptable forms of therapeutic hydrogen sulfide. Recent years have seen a significantly increased level of interests in gaseous signaling molecules, which include nitric oxide (NO), carbon monoxide (CO), and hydrogen sulfide. These molecules are produced endogenously and play key regulatory roles in mammals. Naturally, they are also excellent targets for the development of therapeutics. One key challenge in developing gaseous molecules as therapeutics is in their safe and controlled delivery. Prodrug is a very effective approach to address this challenge. Cancer metastasis is the primary cause of morbidity and mortality, and responsible for about 90% of cancer deaths. Although cancer survival rate has been significantly improved over the years, the improvement is primarily due to early diagnosis and cancer growth inhibition. Limited progress has been made in the treatment of cancer metastasis. Xiangming Guan provides an overview of the metastatic process with a focus on the four essential steps (detachment, migration, invasion and adhesion), related biochemical parameters, and targets for metastasis prevention and inhibition.