CCN3 and calcium signaling.
CCN3 and calcium signaling.
复制标题
DOI：
10.1186/1478-811x-1-1
复制
发表时间：
2003-08-15
期刊：
影响因子：
--
通讯作者：
Perbal, Bernard
中科院分区：
文献类型：
--
作者：
Lombet, Alain;Planque, Nathalie;Perbal, Bernard
CCN基因家族目前在人类中由6个成员组成，又称Cyr61(富含半胱氨酸半胱氨酸)、CTGF(结缔组织生长因子)、NOV(肾母细胞瘤过表达基因)、WISP-1、2和3(WNT-1诱导的分泌蛋白)。过去十年的研究结果表明，CCN蛋白是一种基质细胞蛋白，参与细胞的增殖、分化、存活、黏附和迁移等多种功能的调节。CCN蛋白最近被认为是参与细胞内外信号传递的调节因子。据报道，CCN3与纤毛蛋白-1C、整合素、Notch和S100A4发生物理相互作用。考虑到这些蛋白的构象和生物活性依赖于钙结合，我们推测CCN3可能参与了钙离子介导的信号通路。在本文中，我们回顾了CCN3调节细胞内钙水平的数据，并讨论了可能解释CCN3生物学效应的模型。
The CCN family of genes consists presently of six members in human (CCN1-6) also known as Cyr61 (Cystein rich 61), CTGF (Connective Tissue Growth Factor), NOV (Nephroblastoma Overexpressed gene), WISP-1, 2 and 3 (Wnt-1 Induced Secreted Proteins). Results obtained over the past decade have indicated that CCN proteins are matricellular proteins, which are involved in the regulation of various cellular functions, such as proliferation, differentiation, survival, adhesion and migration. The CCN proteins have recently emerged as regulatory factors involved in both internal and external cell signaling. CCN3 was reported to physically interact with fibulin-1C, integrins, Notch and S100A4. Considering that, the conformation and biological activity of these proteins are dependent upon calcium binding, we hypothesized that CCN3 might be involved in signaling pathways mediated by calcium ions.In this article, we review the data showing that CCN3 regulates the levels of intracellular calcium and discuss potential models that may account for the biological effects of CCN3.