Molecular organization and assembly of the central inhibitory postsynapse.
Molecular organization and assembly of the central inhibitory postsynapse.
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中央抑制性突触后的分子组织和组装。
DOI：
10.1007/400_017
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发表时间：
2006
影响因子：
--
通讯作者：
Moss,StephenJ
中科院分区：
文献类型：
--
作者：
Arancibia-Carcamo,ILorena;Moss,StephenJ
γ-氨基丁酸A型（GABAA）受体是脑内快速突触抑制的主要部位。gaba受体在调节神经元兴奋性方面起着重要作用，此外还与许多神经系统疾病有关。为了理解突触抑制，重要的是要了解细胞机制，神经元利用突触后抑制特化来调节gaba受体的积累和调节。在过去的十年中，许多gaba受体相互作用蛋白的发现使我们能够进一步了解这些受体的运输、靶向和聚集以及受体稳定性的调节。在接下来的综述中，我们将研究gaba受体结合伙伴蛋白和抑制性突触后支架的其他成分，以及它们如何参与抑制性突触的构建和突触抑制的动态调节。
γ-Amino butyric acid type A (GABAA) receptors are the major sites of fast synaptic inhibition in the brain. GABAAreceptors play an important role in regulating neuronal excitability and in addition have been implicated in numerous neurological disorders. In order to understand synaptic inhibition it is important to comprehend the cellular mechanisms, that neurons utilize to regulate the accumulation and regulation of GABAAreceptors at postsynaptic inhibitory specializations. Over the past decade a number of GABAAreceptor interacting proteins have been identified allowing us to further understand the trafficking, targeting and clustering of these receptors as well as the regulation of receptor stability. In the following review we examine the proteins identified as GABAAreceptor binding partners and other components of the inhibitory postsynaptic scaffold, and how they contribute to the construction of inhibitory synapses and the dynamic modulation of synaptic inhibition.