Is nutritional status associated with the level of anxiety, depression and pain in patients with lung cancer?
Is nutritional status associated with the level of anxiety, depression and pain in patients with lung cancer?
复制标题
DOI：
10.21037/jtd.2018.03.108
复制
发表时间：
2018-04-01
影响因子：
2.5
通讯作者：
Rosinczuk, Joanna
中科院分区：
文献类型：
--
作者：
Chabowski, Mariusz;Polanski, Jacek;Rosinczuk, Joanna
背景：营养缺乏在肺癌患者中很常见，特别是在晚期和转移性癌症患者中。癌症患者营养失调的发病机制尚未得到充分解释。这项研究是为了研究营养状况与精神状况和疼痛之间的关系。该研究的目的是评估肺癌患者的营养状况与焦虑、抑郁和感知疼痛水平之间的关系。方法：共纳入257例肺癌患者。采用迷你营养评估问卷（MNA）对其营养状况进行评估；采用医院焦虑抑郁量表（HADS）评估患者的焦虑抑郁水平；采用视觉模拟量表（VAS）评估疼痛感水平。结果：MNA显示，23%的研究组营养不良，33%有营养不良风险，44%营养状况正常。HADS问卷显示，65%的研究组有抑郁症状，65%有焦虑。VAS评分平均为4.35分。营养状况与疼痛呈显著负相关（r = -0.65, P < 0.001），与焦虑、抑郁呈显著负相关（r = -0.68, P < 0.001, r = -0.60, P < 0.001）。结论：肺癌患者营养失调发生率高，躯体症状和心理困扰程度高。与营养状况正常的患者相比，有营养不良风险的患者的抑郁、焦虑和疼痛程度显著，这表明需要早期支持性心理治疗或药物干预。
Background: Nutritional deficiencies are common in lung cancer patients, especially in those with advanced and metastatic cancers. The pathogenesis of the development of nutritional disorders in cancer patients has not been fully explained. The study was performed in order to research associations between nutritional status and mental condition and pain. The aim of the study was to assess the relationship between nutritional status and the level of anxiety, depression and perceived pain in patients with lung cancer.Methods: A total of 257 patients with lung cancer were enrolled. The Mini-Nutritional Assessment (MNA) questionnaire was used to assess their nutritional status; the Hospital Anxiety and Depression Scale (HADS) was used to assess their levels of anxiety and depression; the Visual Analog Scale (VAS) was used to assess levels of perceived pain.Results: The MNA showed that 23% of the study group was malnourished, 33% at risk of malnutrition and 44% displayed a normal nutritional status. The HADS questionnaire showed that 65% of the study group had depressive symptoms and 65% had anxiety. The mean score of the VAS was 4.35. A significant negative correlation between nutritional status and pain was observed (r = -0.65; P < 0.001) as well as between nutritional status and anxiety and depression (r = -0.68; P < 0.001 and r = -0.60; P < 0.001, respectively).Conclusions: The prevalence of nutritional disorders and the intensity of somatic symptoms and psychological distress are high among lung cancer patients. The significant levels of depression, anxiety and pain in patients at risk of malnutrition which were highlighted in comparison to patients with a normal nutritional status indicate the need for early supportive psychotherapy or pharmacological interventions.