The wrapping method using biodegradable felt strips has a preventive effect on the thinning of the aortic wall: Experimental study in the canine aorta
The wrapping method using biodegradable felt strips has a preventive effect on the thinning of the aortic wall: Experimental study in the canine aorta
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DOI：
10.1016/j.jvs.2005.09.044
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发表时间：
2006-02-01
影响因子：
4.3
通讯作者：
Tabayashi, K
中科院分区：
文献类型：
--
作者：
Fujiwara, H;Oda, K;Tabayashi, K
目的：血管外科手术中广泛采用包裹法加固吻合口，但非生物降解毡包裹的主动脉壁在术后的变化尚未得到很好的描述。本研究的目的是阐明非生物降解毛毯在主动脉壁包裹的后遗症，并通过使用生物降解毛毯加或不加碱性成纤维细胞生长因子(BFGF)来改善这些变化。用聚四氟乙烯(PTFE)毡、可生物降解聚乙二醇酸(PGA)和聚乙二醇酸(PGA)包被15只比格犬的胸主动脉，每组5只。3个月后切除降主动脉。测量主动脉壁厚度、中膜和外膜血管密度及管壁强度。结果：PTFE组的中膜厚度明显低于PGA+bFGF组(66%：+/-5%vs85%+/-6%，P
Objectives: Wrapping methods have been widely used to reinforce the anastomotic site in vascular surgery; however, postoperative changes in the aortic wall wrapped by nonbiodegradable felt have not been well characterized. The purposes of this investigation are to elucidate the sequelae of wrapping with nonbiodegradable felt on the aortic wall and to modify those changes by using biodegradable felt with or without basic fibroblast growth factor (bFGF).Methods. The descending thoracic aortas of 15 beagles were wrapped with three different materials: nonbiodegradable polytetrafluoroethylene (PTFE) felt, biodegradable polyglycol acid (PGA) material, and PGA with 100 mu g bFGF (n = 5 in each group). The descending thoracic aorta was resected after 3 months. The thickness of the aortic wall, vessel density in the media and the adventitia, and the wall strength were assessed. Untreated native aortic wall served as a normal control.Results: The thickness of the media of the PTFE group was lower than that of the PGA + bFGF group (66% :+/- 5% vs 85% +/- 6% of control, P