MATURATIONAL CHANGES IN POSTICTAL REFRACTORINESS AND SEIZURE SUSCEPTIBILITY IN DEVELOPING RATS
MATURATIONAL CHANGES IN POSTICTAL REFRACTORINESS AND SEIZURE SUSCEPTIBILITY IN DEVELOPING RATS
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DOI：
10.1002/ana.410130514
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发表时间：
1983-01-01
影响因子：
11.2
通讯作者：
ALBALA, BJ
中科院分区：
文献类型：
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作者：
MOSHE, SL;ALBALA, BJ
在大鼠中测定CNS抑制复发性癫痫发作的能力作为年龄的函数。八个电刺激，以2分钟的时间间隔在成年大鼠和哺乳期大鼠的杏仁核，以前点燃从左杏仁核。在这16分钟的时间内，长期和严重的惊厥反复引起的16日龄大鼠幼崽，而惊厥并不总是引起成年大鼠。结果表明，未成年大鼠比成年大鼠更容易出现癫痫持续状态。随后，使大鼠幼仔和植入但未刺激的同窝仔生长。在成熟时，所有存活的动物都从对侧（右侧）杏仁核点燃。先前点燃的老鼠比同窝出生的老鼠癫痫发作得更快。他们各自的能力，以抑制复发性癫痫发作没有不同的年龄在150和210天，是类似的幼稚控制癫痫发作抑制能力，并显着大于婴儿期的证据。在成年期发生单次癫痫发作的倾向与婴儿癫痫发作史直接相关，而抑制多次癫痫发作的能力是一个动态过程，随年龄而改变，在生命早期最小，并随着成熟而增强，与婴儿惊厥史无关。
The ability of the CNS to suppress recurrent seizures as a function of age was determined in rats. Eight electrical stimulations were delivered to the amygdala at 2-min intervals in adult and suckling rats that were previously kindled from the left amygdala. During this 16-min period, prolonged and severe convulsions were repeatedly elicited in the 16-day-old rat pups, whereas convulsions were not always elicited in adult rats. The results suggest that immature rats are more prone to develop status epilepticus than adult rats. Subsequently, the rat pups and implanted but not stimulated littermates were allowed to grow. At maturity, all the surviving animals were kindled from the contralateral (right) amygdala. The previously kindled rats developed seizures significantly faster than did their littermates. Their respective abilities to suppress recurrent seizures did not differ at 150 and 210 days of age, being similar to the seizure suppression abilities of naive controls and significantly greater than those evidenced in infancy. The propensity to develop single seizures in adulthood is directly related to infant seizure history, whereas the ability to suppress multiple seizures is a dynamic process that is modified by age, being minimal early in life and enhanced with maturation independently of history of infantile convulsions.