Neurodevelopment of children exposed to anesthesia: Design of the Mayo Anesthesia Safety in Kids (MASK) study
Neurodevelopment of children exposed to anesthesia: Design of the Mayo Anesthesia Safety in Kids (MASK) study
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DOI：
10.1016/j.cct.2014.12.020
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发表时间：
2015-03-01
影响因子：
2.2
通讯作者：
Warner, David O.
中科院分区：
文献类型：
--
作者：
Gleich, Stephen J.;Flick, Randall;Warner, David O.
越来越多的证据表明，将动物（包括非人类灵长类动物）发育中的大脑暴露于常用的麻醉剂可能会对认知和行为产生不良影响。在本文中，我们总结了我们的方法，以人口为基础，倾向匹配的研究，以评估可能的麻醉相关的后遗症在学龄前儿童时，在小学或高中。已经确定了1994年至2007年期间在明尼苏达州奥姆斯特德县出生的所有儿童的队列，这些儿童目前是当地居民。现有的医疗记录被用于识别3岁之前暴露于全身麻醉的所有事件（即，在他们三岁生日之前）。在2012年至2016年期间，对8至12岁或15至19岁的多次、单次和无麻醉暴露的儿童进行了抽样检测。为了尽可能接近地匹配不同暴露组的儿童，采样由接受麻醉的可能性的倾向匹配指导。被选中的儿童被邀请参加一个为期4小时的神经心理学测试，包括国家毒理学研究中心-操作测试组合，该组合已被用于研究非人类灵长类动物的麻醉神经毒性。将在具有不同麻醉剂暴露史的儿童中比较该测试的结果。这项研究的预期成果将是利用强大的患者数据库和神经心理学测试电池，对人类可能的麻醉剂相关神经毒性的详细表型进行研究，并首次比较儿童和非人灵长类动物在执行几乎相同的行为任务时麻醉剂暴露的影响。(C)版权所有© 2014 Elsevier Inc.
There is increasing evidence that exposure of developing brains in animals, including nonhuman primates, to commonly-utilized anesthetic agents may cause adverse effects on cognition and behavior. In this paper, we summarize our methodology for a population-based, propensity-matched study to evaluate possible anesthesia-related sequelae in preschool children when evaluated in elementary or high school. A cohort of all children born in Olmsted County, Minnesota between the years 1994 and 2007 who are currently local residents has been identified. Existing medical records are being used to identify all episodes of exposure to general anesthesia prior to the age of 3 years (i.e., prior to their 3rd birthday). Children with multiple, single, and no anesthesia exposure are sampled for testing between the ages of 8 and 12 years or 15 and 19 years during the period 2012-2016. To match children in different exposure groups as closely as possible, sampling is guided by propensity-matching for the likelihood of receiving anesthesia. Selected children are invited to participate in a single 4-hour session of neuropsychological testing, including the National Center for Toxicological Research-Operant Test Battery, which has been used to study anesthetic neurotoxicity in nonhuman primates. The results of this testing will be compared among children with different anesthetic exposure histories. The expected products of this research will be a detailed phenotype of possible anesthetic-associated neurotoxicity in humans, utilizing a robust patient database and neuropsychological testing battery, and the first comparison of effects of anesthetic exposure in children and nonhuman primates performing nearly identical behavioral tasks. (C) 2014 Elsevier Inc All rights reserved.