Real-time radionuclide cineangiography in the noninvasive evaluation of global and regional left ventricular function at rest and during exercise in patients with coronary-artery disease.
Real-time radionuclide cineangiography in the noninvasive evaluation of global and regional left ventricular function at rest and during exercise in patients with coronary-artery disease.
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实时放射性核素电影血管造影对冠状动脉疾病患者静息时和运动时的整体和局部左心室功能进行无创评估。
DOI：
10.1056/nejm197704142961503
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发表时间：
1977
期刊：
影响因子：
--
通讯作者：
G. Johnston
中科院分区：
文献类型：
--
作者：
J. Borer;S. Bacharach;M. Green;K. Kent;S. Epstein;G. Johnston
虽然冠状动脉造影确定了冠状动脉疾病患者的潜在缺血区域，但准确评估缺血的存在和功能重要性需要评估应激期间的局部和整体左心室功能。为了进行这样的评估，我们开发了一种无创实时放射性核素电影血管造影程序，允许连续监测和分析运动过程中的左心室功能。在11例静息时局部和整体心室功能正常的冠心病患者中，运动时出现了新的功能障碍区域（P <0.001），10例患者射血分数下降7 - 47%。在运动过程中，没有一个人出现局部功能障碍，每个人的总体射血分数都增加了（平均增加23 +/-3%[+/-S.E.]，与冠心病患者相比，P <0.001）。运动时放射性核素血管造影术可以准确评估缺血性心脏病的存在和功能严重程度。
Although coronary angiography defines regions of potential ischemia in patients with coronary-artery disease, accurate assessment of the presence and functional importance of ischemia requires appraisal of regional and global left ventricular function during stress. To perform such assessment, we developed a noninvasive real-time radionuclide cineangiographic procedure permitting continuous monitoring and analysis of left ventricular function during exercise. In 11 patients with coronary disease who had normal regional and global ventricular function at rest, new regions of dysfunction developed during exercise (P less than 0.001), and in 10, global ejection fraction dropped 7 to 47 per cent. Fourteen age-matched normal subjects were studied; during exercise none had regional dysfunction, and each increased global ejection fraction (average increase, 23 +/- 3 per cent [+/-S.E.], P less than 0.001 as compared with patients with coronary disease). Radionuclide cineangiography during exercise permits accurate assessment of the presence and functional severity of ischemic heart disease.