tugHall: a simulator of cancer-cell evolution based on the hallmarks of cancer and tumor-related genes
tugHall: a simulator of cancer-cell evolution based on the hallmarks of cancer and tumor-related genes
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DOI：
10.1093/bioinformatics/btaa182
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发表时间：
2020-06-01
期刊：
影响因子：
5.8
通讯作者：
Kato, Mamoru
中科院分区：
文献类型：
--
作者：
Nagornov, Iurii S.;Kato, Mamoru
最近癌症基因组数据的洪流需要一个连贯的模型，可以整理发现，系统地解释克隆进化和由此产生的肿瘤内异质性（ITH）。在这里，我们提出了一个新的数学模型，旨在计算模拟癌细胞的进化。该模型将众所周知的癌症特征与肿瘤相关基因的特定突变状态联系起来。细胞行为表型是随机决定的，而标记可能会干扰表型概率。反过来，标志变量取决于肿瘤相关基因的突变状态。因此，我们的软件可以加深我们对癌细胞进化和ITH产生的理解。
The flood of recent cancer genomic data requires a coherent model that can sort out the findings to systematically explain clonal evolution and the resultant intra-tumor heterogeneity (ITH). Here, we present a new mathematical model designed to computationally simulate the evolution of cancer cells. The model connects the well-known hallmarks of cancer with the specific mutational states of tumor-related genes. The cell behavior phenotypes are stochastically determined, and the hallmarks probabilistically interfere with the phenotypic probabilities. In turn, the hallmark variables depend on the mutational states of tumor-related genes. Thus, our software can deepen our understanding of cancer-cell evolution and generation of ITH.