Environmental and individual exposure to secondhand aerosol of electronic cigarettes in confined spaces: Results from the TackSHS Project†
Environmental and individual exposure to secondhand aerosol of electronic cigarettes in confined spaces: Results from the TackSHS Project†
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DOI：
10.1111/ina.12841
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发表时间：
2021-04-27
期刊：
影响因子：
5.8
通讯作者：
Fernandez, Esteve
中科院分区：
文献类型：
--
作者：
Amalia, Beladenta;Fu, Marcela;Fernandez, Esteve
二手电子烟（电子烟）气溶胶（SHA）可能会损害室内空气质量并暴露于旁观者。本研究旨在研究在模拟真实世界场景的封闭环境的受控条件下暴露于SHA。在汽车和房间中进行了一项实验，其中在30分钟随意使用电子烟期间产生了SHA。在每个环境中连续五天重复实验。我们测量了PM2.5，空气中的尼古丁浓度和暴露于SHA的生物标志物，如尼古丁代谢物，烟草特有的亚硝胺，丙二醇和甘油在旁观者的唾液样本之前，期间和之后的暴露期。还记录了与暴露于SHA相关的自我报告的健康症状。结果显示，在暴露期间记录到最高的PM2.5浓度中位数，在室内环境中为21 μ g/m3，在汽车环境中为16 μ g/m3，与基线相比增加了约两倍。在两种环境中，空气中尼古丁和所有生物标志物的大多数浓度均低于定量限。两种环境中的旁观者都经历了一些短期刺激症状，表现为喉咙干燥，鼻子，眼睛和痰。总之，在密闭空间短期使用电子烟会增加室内PM2.5水平，并在旁观者中引起一些刺激症状。
Secondhand electronic cigarette (e-cigarette) aerosol (SHA) might impair indoor air quality and expose bystanders. This study aims to investigate exposure to SHA in controlled conditions of enclosed settings simulating real-world scenario. An experiment was performed in a car and in a room, in which SHA was generated during a 30-minute ad libitum use of an e-cigarette. The experiment was replicated on five consecutive days in each setting. We measured PM2.5, airborne nicotine concentrations, and biomarkers of exposure to SHA, such as nicotine metabolites, tobacco-specific nitrosamines, propylene glycol, and glycerol in bystanders' saliva samples before, during, and after the exposure period. Self-reported health symptoms related to exposure to SHA were also recorded. The results showed that the highest median PM2.5 concentration was recorded during the exposure period, being 21 mu g/m(3) in the room setting and 16 mu g/m(3) in the car setting-about twofold increase compared to the baseline. Most concentrations of the airborne nicotine and all biomarkers were below the limit of quantification in both settings. Bystanders in both settings experienced some short-term irritation symptoms, expressed as dry throat, nose, eyes, and phlegm. In conclusion, short-term use of an e-cigarette in confined spaces increased indoor PM2.5 level and caused some irritation symptoms in bystanders.