The continuing crisis in antibiotic resistance
The continuing crisis in antibiotic resistance
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DOI：
10.1016/s0924-8579(10)70003-0
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发表时间：
2010-11-01
影响因子：
10.8
通讯作者：
French, G. L.
中科院分区：
文献类型：
--
作者：
French, G. L.
细菌病原体中出现抗生素耐药性是抗生素使用的必然结果。尽管一再发出警告，但疏忽的抗生素使用和糟糕的感染控制做法导致了全球范围内广泛的耐药性问题的持续发展。耐多药病原体现在的特点是异质性，毒力增加，甚至对储备制剂产生抗药性，并在医院和社区内和之间传播。例如耐糖肽的耐甲氧西林金黄色葡萄球菌(MRSA)和肠球菌、产超广谱β-内酰胺酶和碳青霉烯酶的大肠埃希菌，以及产毒素的艰难梭菌。迫切需要有效的国家和国际控制方案来解决这些问题。最近英国耐甲氧西林金黄色葡萄球菌和艰难梭菌感染的大幅减少证明了这种协调努力取得成功的潜力。(C)2010年Elsevier B.V.和国际化疗学会。版权所有。
The emergence of antibiotic resistance in bacterial pathogens is an inevitable consequence of antibiotic use. Despite repeated warnings, negligent antibiotic use and poor infection-control practice have led to the continuing development of extensive resistance problems worldwide. Multidrug-resistant pathogens are now characterized by their heterogeneity, increasing virulence, resistance even to reserve agents and spread within and between hospitals and the community. Examples are glycopeptide-resistant meticillin-resistant Staphylococcus aureus (MRSA) and enterococci, extended-spectrum beta-lactamase- and carbapenemase-producing coliforms, and toxin-hyperproducing Clostridium difficile. Effective national and international programmes of control to combat these problems are urgently needed. The potential for success of such coordinated efforts has been demonstrated by the recent dramatic reductions in MRSA and C. difficile infections in England. (C) 2010 Elsevier B.V. and the International Society of Chemotherapy. All rights reserved.