Copper-Associated Hepatopathy in a Mexican Fruit Bat (Artibeus Jamaicensis) and Establishment of a Reference Range for Hepatic Copper in Bats
Copper-Associated Hepatopathy in a Mexican Fruit Bat (Artibeus Jamaicensis) and Establishment of a Reference Range for Hepatic Copper in Bats
复制标题
墨西哥果蝠（Artibeus Jamaicensis）铜相关性肝病及蝙蝠肝铜参考范围的建立
DOI：
10.1177/104063870401600619
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发表时间：
2004
影响因子：
1.5
通讯作者：
K. Williams
中科院分区：
文献类型：
--
作者：
M. Hoenerhoff;K. Williams
铜毒性已被描述在许多国内物种。其特征性病变包括血红蛋白尿性肾病、肝碎片状坏死伴胆管增生及门脉纤维化。某些物种，如绵羊，当暴露于饲料中的铜时容易中毒，而铜储存的固有遗传缺陷存在于某些品种的狗（贝德灵顿梗，西高地白色梗，杜宾犬）。在非家养物种中，尚未确定内脏中铜的参考范围，因此很难确定铜毒性作为诊断。铜中毒的情况下，圈养墨西哥果蝠。肝脏铜水平在16个额外的蝙蝠，至少3个不同的物种，进行了测量。据作者所知，这是第一例报道的铜中毒的翼手目。
Copper toxicity has been described in numerous domestic species. The characteristic lesions include hemoglobinuric nephrosis and piecemeal hepatic necrosis with bile ductular hyperplasia and portal fibrosis. Certain species, such as sheep, are prone to toxicity when exposed to copper in feed, whereas an inherent genetic defect of copper storage is present in some breeds of dogs (Bedlington Terriers, West Highland White Terriers, Doberman Pinschers). In nondomestic species, reference ranges have not been established for copper in internal organs, so the establishment of copper toxicity as a diagnosis is difficult. A case of copper toxicity in a captive Mexican fruit bat is presented. Hepatic copper levels in 16 additional bats, of at least 3 different species, were measured. To the authors' knowledge, this is the first reported case of copper toxicity in a chiropteran.