The problem of malaria and malaria control in pregnancy in sub-Saharan Africa
The problem of malaria and malaria control in pregnancy in sub-Saharan Africa
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DOI：
10.4269/ajtmh.1996.55.2
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发表时间：
1996-01-01
影响因子：
3.3
通讯作者：
Breman, JG
中科院分区：
文献类型：
--
作者：
Steketee, RW;Wirima, JJ;Breman, JG
孕妇感染恶性疟原虫常常导致胎盘感染和婴儿出生体重过低（< 2500克），特别是在撒哈拉以南非洲疟疾高传播地区。众所周知，低出生体重是婴儿早期死亡的一个重要危险因素。为了降低孕产妇感染对儿童生存构成的风险，许多产前诊所规划建议并提供抗疟化学预防，通常将氯喹（CQ）作为产前保健的推荐元素。在20世纪80年代之前，尽管这种干预措施得到了广泛的倡导，但人们对这种干预策略的效果知之甚少。作为对Mangochi疟疾研究项目的介绍，我们描述了非洲孕妇疟疾感染的知识背景以及干预和预防战略的重要要素。Mangochi疟疾研究项目研究了马拉维孕妇使用CQ或甲氟喹的几种抗疟疾方案的疗效。
Plasmodium falciparum infection in pregnant women frequently leads to placental infection and low birth weight (< 2,500 grams) of the infant, particularly in the areas of high malaria transmission found in sub-Saharan Africa. Low birth weight is widely known to be an important risk factor for early infant mortality. To reduce the risk that maternal infection poses to child survival, many antenatal clinic programs recommend and provide antimalarial chemoprophylaxis, often with chloroquine (CQ) as a recommended element for antenatal care. Prior to the 1980s, despite widespread advocacy for this intervention, little was known about the effect of this intervention strategy. As an introduction to the Mangochi Malaria Research Project, which examined the efficacy of several antimalarial regimens using CQ or mefloquine in pregnant women in Malawi, we describe the background of knowledge regarding malaria infection in pregnant African women and the important elements of an intervention and prevention strategy.