Severe capillary leak syndrome with cardiac arrest triggered by influenza virus infection.
Severe capillary leak syndrome with cardiac arrest triggered by influenza virus infection.
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DOI：
10.1136/bcr-2018-226108
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发表时间：
2018-08-29
期刊：
影响因子：
0.9
通讯作者：
Mogensen, Trine Hyrup
中科院分区：
文献类型：
--
作者：
Ebdrup, Lotte;Druey, Kirk M;Mogensen, Trine Hyrup
全身性毛细血管渗漏综合征(SCLS)，也称为Clarkson综合征，是一种罕见的疾病，具有潜在的致命后果。临床表现包括液体和蛋白质从血液中渗漏到周围组织，导致低蛋白血症、红细胞压积升高、水肿和低血压。症状的范围从四肢的离散肿胀/水肿到暴发性心源性休克。我们报告一位52岁男性在从心跳骤停中苏醒后被诊断为小儿麻痹症的病例，并伴有间隔室综合征。这起严重的毛细血管泄漏事件可能是由流感病毒感染引发的。事后看来，他在重大急性发作前2年出现了小儿麻痹症的症状。在这里，我们描述了这一病例，并回顾了一些关于SCLS的文献，特别是关于其发病机制、治疗/预防以及长期的生理和心理并发症。
Systemic capillary leak syndrome (SCLS), also known as Clarkson syndrome, is a rare disease with potential fatal outcome. The clinical picture involves leakage of fluid and protein from the bloodstream into peripheral tissues, resulting in hypoalbuminaemia, elevated haematocrit, oedema and hypotension. The spectrum of the symptoms ranges from discrete swelling/oedema of extremities to fulminant cardiogenic shock. We present a case with a 52-year-old man diagnosed with SCLS after being resuscitated from cardiac arrest, which was complicated by compartment syndrome. The severe episode of capillary leak was potentially triggered by influenza virus infection. With the benefit of hindsight, he presented with symptoms of SCLS 2 years prior the major acute episode. Here we describe this case and review some aspects of the literature on SCLS, with particular focus on the pathogenesis, treatment/prophylaxis and long-term physical and psychological complications.