Cerebrospinal Fluid Tau and Phosphorylated Tau Protein are Elevated in Corticobasal Syndrome
Cerebrospinal Fluid Tau and Phosphorylated Tau Protein are Elevated in Corticobasal Syndrome
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DOI：
10.1002/mds.23341
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发表时间：
2011-01-01
影响因子：
8.6
通讯作者：
Verbeek, M. M.
中科院分区：
文献类型：
--
作者：
Aerts, M. B.;Esselink, R. A. J.;Verbeek, M. M.
区分皮质基底综合征（CBS）与进行性核上性麻痹（PSP）和特发性帕金森病（PD）可能很困难。为了研究脑脊液（CSF）生物标志物在帕金森综合征诊断鉴别中的附加价值，我们分析了PSP（n = 5 - 21）、CBS（n = 12）、PD（n = 28）。与PSP和PD患者相比，CBS患者表现出更高的t-tau和p-tau浓度。在区分CBS和PD时，ttau提供了最佳的敏感性（75%）和特异性（90.9%）组合，其次是p-tau（敏感性87.5%和特异性75%）。p-tau/ t-tau比值鉴别PSP和CBS的敏感性为84.2%，特异性为66.7%。总之，我们的研究结果表明，CSF参数在CBS和PD的诊断鉴别中具有额外的价值。(C)2010年运动障碍协会
Differentiating corticobasal syndrome (CBS) from progressive supranuclear palsy (PSP) and idiopathic Parkinson's disease (PD) can be difficult. To investigate the additional value of cerebrospinal fluid (CSF) biomarkers in the diagnostic differentiation of parkinsonism, we analyzed the CSF concentrations of total protein, lactate and brain specific proteins amyloid-beta 42 protein, tau protein (t-tau), and tau protein phosphorylated at Thr181 (p-tau), in CSF samples from patients with PSP (n 5 21), CBS (n = 12), and PD (n = 28). CBS patients demonstrated higher concentrations of t-tau and p-tau compared with PSP and PD patients. In discriminating CBS and PD, ttau offered the best combination of sensitivity (75%) and specificity (90.9%), followed by p-tau (sensitivity 87.5% and specificity 75%). The p-tau/ t-tau ratio resulted in sensitivity of 84.2% and specificity of 66.7% in discriminating PSP and CBS. In conclusion, our results suggest that CSF parameters are of additional value in the diagnostic differentiation of CBS and PD. (C) 2010 Movement Disorder Society