Mucinous ovarian tumors of mullerian-type:: An analysis of 17 cases including borderline tumors and intraepithelial, microinvasive, and invasive carcinomas
Mucinous ovarian tumors of mullerian-type:: An analysis of 17 cases including borderline tumors and intraepithelial, microinvasive, and invasive carcinomas
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DOI：
10.1097/01.pgp.0000152024.37482.63
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发表时间：
2005-04-01
影响因子：
2.4
通讯作者：
Têtu, B
中科院分区：
文献类型：
--
作者：
Dubé, V;Roy, M;Têtu, B
卵巢苗勒型粘液性肿瘤（MMT）的特征是乳头状结构类似于浆液性肿瘤，内容物为宫颈样粘液上皮。后者可与其他苗勒氏型上皮细胞混合，包括浆液性、类浆液性和鳞状上皮细胞，以及中性嗜酸性上皮细胞。我们分析了17例MMT，包括12例交界性肿瘤，2例上皮内癌，2例微浸润性癌和1例浸润性癌。16例肿瘤中有14例（88%）分期为1期;其余2例（均为交界性）为IIa期和IIIc期。子宫内膜异位症被确定在8例（47%）。只有两名患者（12%）有双侧肿瘤，双侧发生的频率低于以往的研究。5名患者（31%）接受了保守治疗，包括囊肿切除术或单侧输卵管卵巢切除术。所有患者的预后良好，无复发或疾病相关死亡，无论是否存在高有丝分裂指数、上皮内癌、微浸润、双侧性、保守治疗或晚期。MMT的这种惰性行为与以前报道的相似，但需要在这一类中增加浸润性癌的病例以更好地确定其结果。
Mullerian-type mucinous tumors (MMTs) of the ovary are characterized by a papillary architecture similar to that of serous tumors and a content of endocervicallike mucinous epithelium. The latter may be admixed with other mullerian-type epithelia, including those of serous, endometrioid, and squamous types, and indifferent eosinophilic epithelial cells. We analyzed 17 MMTs, including 12 borderline tumors, 2 intraepithelial carcinomas, 2 microinvasive carcinomas, and I invasive carcinoma. Fourteen of 16 tumors (88%) with available staging were stage 1; the remaining two cases (both borderline) were stage IIa and IIIc. Endometriosis was identified in eight cases (47%). Only two patients (12%) had bilateral tumors, a frequency of bilaterality lower than in previous studies. Five patients (31%) had conservative treatment consisting of a cystectomy or unilateral salpingo-oophorectomy. All patients had a favorable outcome, with no recurrences or disease-related deaths, regardless of the presence of high mitotic index, intraepithelial carcinoma, microinvasion, bilaterality, conservative treatment, or advanced stage. This indolent behavior of MMTs is similar to that previously reported, but additional cases of invasive carcinomas in this category are needed to better define their outcome.