Hyperbaric polymer microcapsules for tunable oxygen delivery.
Hyperbaric polymer microcapsules for tunable oxygen delivery.
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DOI：
10.1016/j.jconrel.2020.08.003
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发表时间：
2020-08
期刊：
影响因子：
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通讯作者：
Tien Nguyen;Yifeng Peng;Raymond P. Seekell;J. Kheir;B. Polizzotti
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作者：
Tien Nguyen;Yifeng Peng;Raymond P. Seekell;J. Kheir;B. Polizzotti
在过去的十年里，人们多次尝试设计能够输送氧气的系统，以克服由于创伤性损伤、细胞移植或肿瘤生长等原因而发生的全身和局部缺氧的影响。尽管在这一领域取得了进展，这导致了一类新的产氧生物材料，但大多数报道的技术缺乏独立控制氧通量（每单位时间的体积）和输送持续时间所必需的可调性，这两者都是克服不同病因的组织缺氧的关键参数。在这里，我们表明，这些关键参数可以有效地操纵使用hyperbarically-loaded聚合物微胶囊（PMC）。PMC是具有中空核和聚合物壳的微米级颗粒。我们表明，通过PMC的氧气输送是依赖于它的渗透性，通过聚合物壳，壳的厚度，和跨壳的压力梯度。我们还证明，将中间油层之间的聚合物壳和气体核心，防止快速脱气，有效地降低所产生的压力梯度后减压的聚合物膜。
Over the past decade, there have been many attempts to engineer systems capable of delivering oxygen to overcome the effects of both systemic and local hypoxia that occurs as a result of traumatic injury, cell transplantation, or tumor growth, among many others. Despite progress in this field, which has led to a new class of oxygen-generating biomaterials, most reported techniques lack the tunability necessary for independent control over the oxygen flux (volume per unit time) and the duration of delivery, both of which are key parameters for overcoming tissue hypoxia of varying etiologies. Here, we show that these critical parameters can be effectively manipulated using hyperbarically-loaded polymeric microcapsules (PMC). PMCs are micron-sized particles with hollow cores and polymeric shells. We show that oxygen delivery through PMCs is dependent on its permeability through the polymeric shell, the shell thickness, and the pressure gradient across the shell. We also demonstrate that incorporating an intermediate oil layer between the polymeric shell and the gas core prevents rapid outgassing by effectively lowering the resultant pressure gradient across the polymeric membrane following depressurization.