Neurocognitive deficits and functional outcome in schizophrenia: Are we measuring the "right stuff"?
Neurocognitive deficits and functional outcome in schizophrenia: Are we measuring the "right stuff"?
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DOI：
10.1093/oxfordjournals.schbul.a033430
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发表时间：
2000-01-01
影响因子：
6.6
通讯作者：
Mintz, J
中科院分区：
文献类型：
--
作者：
Green, MF;Kern, RS;Mintz, J
人们对精神分裂症患者神经认知缺陷的功能后果产生了浓厚的兴趣。这一领域发表的文献在过去几年里翻了一番。在本文中，我们将试图证实先前综述的结论，即某些神经认知领域（次级言语记忆、即时记忆、通过卡片分类测量的执行功能和警惕性）与功能结果相关。除了调查重复发现的数量和计算结果的方框分数外，我将通过应用元分析以更彻底和实证的方式对研究进行审查。最后，我们将讨论我们认为这一文献的一个关键限制，特别是相对狭窄的预测指标选择。这一限制限制了可能解释这些关系机制的中介变量的识别。
There has been a surge of interest in the functional consequences of neurocognitive deficits in schizophrenia. The published literature in this area has doubled in the last few years. In this paper, we will attempt to confirm the conclusions from a previous review that certain neurocognitive domains (secondary verbal memory, immediate memory, executive functioning as measured by card sorting, and vigilance) are associated with functional outcome. In addition to surveying the number of replicated findings and tallying box scores of results, me will approach the review of the studies in a more thorough and empirical manner by applying a meta-analysis. Lastly, we mill discuss what we see as a key limitation of this literature, specifically, the relatively narrow selection of predictor measures. This limitation has constrained identification of mediating variables that may explain the mechanisms for these relationships.