Antenatal diagnosis of intrauterine infection with coxsackievirus B3 associated with live birth.
Antenatal diagnosis of intrauterine infection with coxsackievirus B3 associated with live birth.
复制标题
DOI：
10.1080/1064744042000210357
复制
发表时间：
2004
影响因子：
--
通讯作者：
Fung, Karen Fung Kee
中科院分区：
文献类型：
--
作者：
Ouellet, Annie;Sherlock, Rebecca;Toye, Baldwin;Fung, Karen Fung Kee
背景：先前报道的死产和新生儿感染肠道病毒的病例提示经胎盘感染。我们介绍一例胎儿感染柯萨奇病毒 B3 的病例，该病例在产前诊断并导致活产。病例：一名孕妇在 26 周时出现胎儿心动过速和非免疫性胎儿水肿。柯萨奇病毒 B3 是从羊水中培养出来的。柯萨奇病毒 B3 母体抗体在 1:512 呈阳性。 32周时，胎儿状况恶化并分娩。脐带血柯萨奇病毒 B3 抗体呈较高滴度阳性。新生儿死亡后，通过聚合酶链反应，脑和胎盘组织肠道病毒核糖核酸呈阳性。结论：非免疫性胎儿水肿的鉴别诊断应考虑肠道病毒宫内感染。柯萨奇病毒 B3 感染的产前诊断与不良结局相关。
BACKGROUND: Prior reported cases of stillbirth and neonates infected with enteroviruses suggest transplacental infection. We present a case of fetal infection with coxsackievirus B3, diagnosed antenatally and resulting in live birth. CASE: A pregnant woman presented at 26 weeks with fetal tachycardia and non-immune hydrops fetalis. Coxsackievirus B3 was cultured from amniotic fluid. Maternal antibody to coxsackievirus B3 was positive at 1:512. At 32 weeks, the fetus deteriorated and was delivered. Cord blood antibody to coxsackievirus B3 was positive at a higher titer. Following neonatal death, brain and placental tissues were positive for enterovirus ribonucleic acid by polymerase chain reaction. CONCLUSION: Intrauterine infection by enteroviruses should be considered in the differential diagnosis of non-immune hydrops fetalis. Antenatal diagnosis of coxsackievirus B3 infection is associated with poor outcome.