Nuclear factor kappaB-activated monocytes contribute to pancreatic cancer progression through the production of Shh
Nuclear factor kappaB-activated monocytes contribute to pancreatic cancer progression through the production of Shh
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DOI：
10.1007/s00262-009-0783-7
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发表时间：
2010-05
期刊：
影响因子：
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通讯作者：
A. Yamasaki;C. Kameda;R. Xu;Haruo Tanaka;Takehiko Tasaka;N. Chikazawa;Hiroyuki Suzuki;T. Morisaki;M. Kubo;H. Onishi;Masao Tanaka;M. Katano
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文献类型：
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作者：
A. Yamasaki;C. Kameda;R. Xu;Haruo Tanaka;Takehiko Tasaka;N. Chikazawa;Hiroyuki Suzuki;T. Morisaki;M. Kubo;H. Onishi;Masao Tanaka;M. Katano
最近，据报道，Hh信号在肿瘤基质细胞中被激活，但在肿瘤细胞本身中不被激活，并且基质细胞可能在癌细胞的增殖中起作用。这表明基质细胞在肿瘤细胞增殖中可能通过Hh信号传导介导的重要作用。在这份报告中，我们首次提出，炎症刺激的单核细胞通过激活NF-κB信号通路产生Shh，并通过Hh信号通路以旁分泌方式促进胰腺癌细胞的增殖。
Recently, it was reported that Hh signaling is activated in tumor stromal cells but not in tumor cells themselves and that stromal cells may play a role in the proliferation of cancer cells. This suggests the possibility that stromal cells have an important role in the proliferation of tumor cells that may be mediated through Hh signaling. In this report, we present for the first time that inflammation-stimulated monocytes produce Shh through activation of the NF-κB signaling pathway, and that the Shh produced promotes the proliferation of pancreatic cancer cells in a paracrine manner through Hh signaling.